• 2054 引文
  • 23 h-指數
19972020
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研究成果 1997 2019

  • 2054 引文
  • 23 h-指數
  • 63 Article
  • 5 Review article
  • 1 Letter
2019

Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis

Yen, C-J., Yang, S. T., Chen, R. Y., Huang, W-Y., Chayama, K., Lee, M. H., Yang, S. J., Lai, H. S., Yen, H. Y., Hsiao, Y. W., Wang, J-M., Lin, Y-J. & Hung, L-Y., 2019 六月 6, 於 : Journal of biomedical science. 26, 1, 44.

研究成果: Article

開啟存取
Proteins
Hepatocellular Carcinoma
Viruses
Hepatitis B virus
Cyclic AMP Response Element-Binding Protein
2018

Ground glass hepatocytes provide targets for therapy or prevention of hepatitis B virus-related hepatocellular carcinoma

Chang, H., Tsai, H., Teng, C., Hui-ching Wang, L., Huang, W. & Su, I., 2018 三月 1, 於 : AIMS Medical Science. 5, 2, p. 90-101

研究成果: Article

5 引文 (Scopus)

Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection

Yen, C. J., Ai, Y. L., Tsai, H. W., Chan, S. H., Yen, C. S., Cheng, K. H., Lee, Y. P., Kao, C. W., Wang, Y. C., Chen, Y. L., Lin, C. H., Liu, T., Tsai, H. P., Wang, J. R., Su, I. J. & Huang, W., 2018 九月, 於 : Hepatology. 68, 3, p. 815-826 12 p.

研究成果: Article

Hepatitis B virus
Hepatocellular Carcinoma
Biomarkers
Recurrence
Surface Antigens

Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection

Yen, C., Ai, Y., Tsai, H., Chan, S., Yen, C., Cheng, K., Lee, Y., Kao, C., Wang, Y., Chen, Y., Lin, C., Liu, T., Tsai, H., Wang, J., Su, I. & Huang, W., 2018 九月 1, 於 : Hepatology. 68, 3, p. 815-826

研究成果: Article

1 引文 (Scopus)

NEK2 promotes hepatoma metastasis and serves as biomarker for high recurrence risk after hepatic resection

Chang, Y. Y., Yen, C-J., Chan, S-H., Chou, Y. W., Lee, Y. P., Bao, C. Y., Huang, C. J. & Huang, W-Y., 2018 九月 1, 於 : Annals of Hepatology. 17, 5, p. 843-856 14 p.

研究成果: Article

Hepatocellular Carcinoma
Biomarkers
Neoplasm Metastasis
Recurrence
Liver

NEK2 Promotes Hepatoma Metastasis and Serves as Biomarker for High Recurrence Risk after Hepatic Resection

Chang, Y., Yen, C., Chan, S., Chou, Y., Lee, Y., Bao, C., Huang, C. & Huang, W., 2018 八月 24, 於 : Annals of Hepatology. 17, 5, p. 843-856

研究成果: Article

2016
10 引文 (Scopus)

A biphasic response pattern of lipid metabolomics in the stage progression of hepatitis B virus X tumorigenesis

Teng, C. F., Hsieh, W. C., Yang, C. W., Su, H. M., Tsai, T. F., Sung, W. C., Huang, W-Y. & Su, I. J., 2016 一月 1, 於 : Molecular Carcinogenesis. 55, 1, p. 105-114 10 p.

研究成果: Article

Metabolomics
Hepatitis B virus
Carcinogenesis
Lipids
1-Acylglycerol-3-Phosphate O-Acyltransferase
8 引文 (Scopus)

Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Yen, T. T. C., Yang, A., Chiu, W-T., Li, T. N., Wang, L. H., Wu, Y. H., Wang, H. C., Chen, L., Wang, W. C., Huang, W-Y., Chang, C. W., Chang, M. D. T., Shen, M-R., Su, I. J. & Wang, L. H. C., 2016 四月 26, 於 : Oncotarget. 7, 17, p. 23346-23360 15 p.

研究成果: Article

Chromosomal Instability
Surface Antigens
Hepatitis B virus
Calcium
Endoplasmic Reticulum
7 引文 (Scopus)
Chronic Hepatitis B
Antiviral Agents
Glass
Hepatocytes
Hepatocellular Carcinoma
5 引文 (Scopus)
Double-Stranded DNA Breaks
Pharmaceutical Preparations
DNA End-Joining Repair
DNA-Activated Protein Kinase
Epirubicin
2015
12 引文 (Scopus)

Hepatitis B virus pre-S2 mutant induces aerobic glycolysis through mammalian target of rapamycin signal cascade

Teng, C. F., Hsieh, W. C., Wu, H. C., Lin, Y. J., Tsai, H. W., Huang, W. & Su, I. J., 2015 四月 24, 於 : PloS one. 10, 4, e0122373.

研究成果: Article

Hepatitis B virus
glycolysis
Glycolysis
Sirolimus
Viruses
16 引文 (Scopus)

Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis

Hsieh, Y. H., Chang, Y. Y., Su, I. J., Yen, C-J., Liu, Y. R., Liu, R. J., Hsieh, W. C., Tsai, H-W., Wang, L. H. C. & Huang, W-Y., 2015 七月 1, 於 : Journal of Pathology. 236, 3, p. 337-347 11 p.

研究成果: Article

Double-Stranded DNA Breaks
Genomic Instability
Hepatitis B virus
Membrane Proteins
Karyopherins
2014
2 引文 (Scopus)
Human Herpesvirus 4
Hodgkin Disease
Hepatitis B virus
Viruses
Endoplasmic Reticulum Stress
32 引文 (Scopus)

The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis

Su, I. J., Wang, L. H. C., Hsieh, W. C., Wu, H. C., Teng, C. F., Tsai, H-W. & Huang, W-Y., 2014 一月 1, 於 : Journal of biomedical science. 21, 1, 98.

研究成果: Review article

Mutant Proteins
Endoplasmic Reticulum Stress
Viruses
Hepatitis B virus
Carcinogenesis
5 引文 (Scopus)

Verification of wild-type EGFR status in non-small cell lung carcinomas using a mutant-enriched PCR on selected cases

Chen, Y. L., Lu, C-C., Yang, S. C., Su, W-P., Lin, Y. L., Chen, W. L., Huang, W-Y., Su, W-C., Chow, N-H. & Ho, C-L., 2014 一月 1, 於 : Journal of Molecular Diagnostics. 16, 5, p. 486-494 9 p.

研究成果: Article

Non-Small Cell Lung Carcinoma
Peptide Nucleic Acids
Polymerase Chain Reaction
Mutation
DNA
2013
16 引文 (Scopus)

Essential role of β-human 8-oxoguanine DNA glycosylase 1 in mitochondrial oxidative DNA repair

Su, Y. H., Lee, Y. L., Chen, S. F., Lee, Y. P., Hsieh, Y. H., Tsai, J. H., Hsu, J. L., Tian, W. T. & Huang, W-Y., 2013 一月 1, 於 : Environmental and Molecular Mutagenesis. 54, 1, p. 54-64 11 p.

研究成果: Article

DNA Glycosylases
Mitochondrial DNA
DNA Repair
Mitochondrial Membranes
Electron Transport Complex I
16 引文 (Scopus)

Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis b virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients

Hsieh, Y. H., Su, I. J., Yen, C. J., Tsai, T. F., Tsai, H. W., Tsai, H. N., Huang, Y. J., Chen, Y. Y., Ai, Y. L., Kao, L. Y., Hsieh, W. C., Wu, H. C. & Huang, W., 2013 二月 1, 於 : Carcinogenesis. 34, 2, p. 475-485 11 p.

研究成果: Article

Hepatitis Viruses
Histone Deacetylase Inhibitors
Oncogene Proteins
Chronic Hepatitis B
Hepatitis B virus
2 引文 (Scopus)

Zinc-dependent interaction between JAB1 and Pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis

Hsu, J. L., Chuang, W-J., Su, I. J., Gui, W. J., Chang, Y. Y., Lee, Y. P., Ai, Y. L., Chuang, D. T. & Huang, W-Y., 2013 十二月 1, 於 : Journal of Virology. 87, 23, p. 12675-12684 10 p.

研究成果: Article

Hepatitis B virus
surface antigens
Surface Antigens
binding proteins
Zinc
2012
37 引文 (Scopus)
Cyclin A
Centrosome
Cyclins
Hepatitis B virus
Endoplasmic Reticulum Stress
20 引文 (Scopus)

Crystal structure and DNA-binding mode of Klebsiella pneumoniae primosomal PriB protein

Huang, Y. H., Lo, Y. H., Huang, W-Y. & Huang, C. Y., 2012 十月 1, 於 : Genes to Cells. 17, 10, p. 837-849 13 p.

研究成果: Article

Klebsiella pneumoniae
Single-Stranded DNA
Proteins
Nucleic Acids
Databases
9 引文 (Scopus)

Human herpesvirus 8-associated lymphoma mimicking cutaneous anaplastic large T-cell lymphoma in a patient with human immunodeficiency virus infection

Li, M. F., Hsiao, C. H., Chen, Y. L., Huang, W-Y., Lee, Y. H., Huang, H. N. & Lien, H. C., 2012 二月 1, 於 : Journal of Cutaneous Pathology. 39, 2, p. 274-278 5 p.

研究成果: Article

Anaplastic Large-Cell Lymphoma
Human Herpesvirus 8
T-Cell Lymphoma
Virus Diseases
Primary Effusion Lymphoma
8 引文 (Scopus)
Langerhans Cells
Acute Myeloid Leukemia
Dendritic Cells
Myeloproliferative Disorders
Leukemia, Myelomonocytic, Chronic
2011
38 引文 (Scopus)
Hepatitis B virus
Glass
Hepatocytes
Hepatocellular Carcinoma
Hepatitis B Surface Antigens
24 引文 (Scopus)

ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells

Chang, Y. S., Tsai, C. T., Huangfu, C. A., Huang, W. Y., Lei, H. Y., Lin, C. F., Su, I. J., Chang, W. T., Wu, P. H., Chen, Y. T., Hung, J. H., Young, K. C. & Lai, M. D., 2011 三月 1, 於 : Journal of Cellular Biochemistry. 112, 3, p. 881-893 13 p.

研究成果: Article

Glycogen Synthase Kinase 3
Endoplasmic Reticulum Stress
Liver
Up-Regulation
Lipids
22 引文 (Scopus)

Genomic instability caused by hepatitis B virus: Into the hepatoma inferno

Hsieh, Y. H., Hsu, J. L., Su, I. J. & Huang, W-Y., 2011 六月 1, 於 : Frontiers in Bioscience. 16, 7, p. 2586-2597 12 p.

研究成果: Article

Genomic Instability
Viruses
Hepatitis B virus
Hepatocellular Carcinoma
Chromosomal Instability
18 引文 (Scopus)

Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells

Hung, J. H., Teng, Y. N., WangLily, L. H. C., Su, I. J., Wang, C. C. C., Huang, W., Lee, K. H., Lu, K. Y. & Wang, L. H., 2011 十二月 22, 於 : PloS one. 6, 12, e28977.

研究成果: Article

fluorouracil
Hepatitis B virus
surface proteins
Surface Antigens
surface antigens
38 引文 (Scopus)
Sirolimus
Surface Antigens
Hepatitis B virus
Carcinogenesis
Histone Deacetylase 1
2010
4 引文 (Scopus)

Agaricus blazei Murill ameliorates myocardial ischemia-reperfusion injury

Huang, C. H., Tsai, H. N., Peng, R. H., Hsieh, Y. H., Chuang, W-J., Hsu, G. C., Huang, W-Y. & Chen, W. J., 2010 十二月 1, 於 : Acta Cardiologica Sinica. 26, 4, p. 235-241 7 p.

研究成果: Article

Agaricus
Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Myocardial Reperfusion
6 引文 (Scopus)
Acyclovir
Interferon-beta
Virus Diseases
Simplexvirus
Interferons
23 引文 (Scopus)
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
T-Cell Lymphoma
B-Cell Lymphoma
Taiwan
7 引文 (Scopus)

Hepatitis B virus surface antigen interacts with acid alpha-glucosidase and alters glycogen metabolism

Hung, J. H., Yan, C. W., Su, I. J., Wang, H. C., Lei, H. Y., Lin, W. C., Chang, W-T., Huang, W-Y., Lu, T. J. & Lai, M-D., 2010 六月 1, 於 : Hepatology Research. 40, 6, p. 633-640 8 p.

研究成果: Article

Glucosidases
alpha-Glucosidases
Hepatitis B Surface Antigens
Glycogen
Hepatitis B virus
2009
17 引文 (Scopus)

A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers

Shen, F. C., Su, I. J., Wu, H. C., Hsieh, Y. H., Yao, W-J., Young, K-C., Chang, T. C., Hsieh, H. C., Tsai, H. N. & Huang, W-Y., 2009 十月 12, 於 : Journal of biomedical science. 16, 1, 84.

研究成果: Article

Chronic Hepatitis B
Surface Antigens
Oligonucleotide Array Sequence Analysis
Viruses
Hepatitis B virus
79 引文 (Scopus)

Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis

Yang, J. C., Teng, C. F., Wu, H. C., Tsai, H-W., Chuang, H. C., Tsai, T. F., Hsu, Y. H., Huang, W-Y., Wu, L-W. & Su, I. J., 2009 六月 1, 於 : Hepatology. 49, 6, p. 1962-1971 10 p.

研究成果: Article

Hepatitis B virus
Vascular Endothelial Growth Factor A
Glass
Hepatocytes
Hepatocellular Carcinoma
13 引文 (Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y-S., Wu, J. J., Lin, M. T., Liu, C-C., Huang, W-Y. & Chuang, W-J., 2009 四月 17, 於 : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

研究成果: Article

streptopain
Substrate Specificity
Substrates
X-Rays
X rays
2008
81 引文 (Scopus)
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Glass
Hepatocytes
7 引文 (Scopus)

Reduced expression of von Hippel-Lindau gene in subjects exposed to polychlorinated biphenyls and dibenzofurans

Tsai, P. C., Wang, Y-J., Tsai, J. H., Guo, Y. L., Ueng, T. H., Liu, H-S. & Huang, W-Y., 2008 十月 1, 於 : Environmental Research. 108, 2, p. 247-251 5 p.

研究成果: Article

Malformed Nails
Polychlorinated Biphenyls
PCDF
Nails
PCB
4 引文 (Scopus)

Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia

Hsu, J. F., Chuang, W-J., Shiesh, S-C., Lin, Y-S., Liu, C-C., Wang, C. C., Fu, T-F., Tsai, J. H., Tsai, W. L., Huang, Y. J., Hsieh, Y. H., Wu, J. J., Lin, M. T. & Huang, W-Y., 2008 八月 1, 於 : Journal of Infectious Diseases. 198, 3, p. 367-374 8 p.

研究成果: Article

Adenosylhomocysteinase
Cysteine Proteases
Impetigo
Myositis
Pharyngitis
16 引文 (Scopus)
p38 Mitogen-Activated Protein Kinases
Virus Replication
Hepatitis B virus
Antiviral Agents
Hepatocellular Carcinoma
2007
26 引文 (Scopus)

Differential endoplasmic reticulum stress signaling pathways mediated by iNOS

Hsieh, Y. H., Su, I. J., Lei, H. Y., Lai, M-D., Chang, W. W. & Huang, W-Y., 2007 八月 3, 於 : Biochemical and Biophysical Research Communications. 359, 3, p. 643-648 6 p.

研究成果: Article

Endoplasmic Reticulum Stress
Oxidative stress
Nitric Oxide Synthase Type II
Oxidative Stress
Endoplasmic Reticulum
56 引文 (Scopus)

Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1

Hsieh, Y. H., Su, I. J., Wang, H. C., Tsai, J. H., Huang, Y. J., Chang, W. W., Lai, M. D., Lei, H. Y. & Huang, W., 2007 十月 1, 於 : Molecular Cancer Research. 5, 10, p. 1063-1072 10 p.

研究成果: Article

Cyclin-Dependent Kinases
Surface Antigens
Hepatitis B virus
Carrier Proteins
Cyclin-Dependent Kinase 2
46 引文 (Scopus)
Polychlorinated Biphenyls
PCDF
Polychlorinated biphenyls
Liver
PCB
2006
9 引文 (Scopus)
Trigeminal Ganglion
Thymidine Kinase
Simplexvirus
Coinfection
Viruses
23 引文 (Scopus)

Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues

Chen, S. H., Yao, H. W., Huang, W-Y., Hsu, K-S., Lei, H. Y., Shiau, A-L. & Chen, S., 2006 十二月 1, 於 : Journal of Virology. 80, 24, p. 12387-12392 6 p.

研究成果: Article

herpes simplex
Nerve Tissue
Simplexvirus
central nervous system
Central Nervous System
20 引文 (Scopus)

Genetic polymorphisms in CYP1A1 and GSTM1 predispose humans to PCBs/PCDFs-induced skin lesions

Tsai, P. C., Huang, W-Y., Lee, Y. C., Chan, S-H. & Guo, Y. L., 2006 五月 1, 於 : Chemosphere. 63, 8, p. 1410-1418 9 p.

研究成果: Article

Cytochrome P-450 CYP1A1
Polychlorinated Biphenyls
dibenzofuran
Genetic Polymorphisms
Polymorphism
47 引文 (Scopus)

Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan

Chang, T. W., Wang, S. M., Guo, Y. L. L., Tsai, P. C., Huang, C. J. & Huang, W., 2006 十二月, 於 : Breast. 15, 6, p. 754-761 8 p.

研究成果: Article

Glutathione Transferase
Taiwan
Breast Neoplasms
Catechol Estrogens
Recombinational DNA Repair
162 引文 (Scopus)

Hepatitis B Virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis

Wang, H. C., Huang, W-Y., Lai, M-D. & Su, I. J., 2006 八月 1, 於 : Cancer Science. 97, 8, p. 683-688 6 p.

研究成果: Review article

Endoplasmic Reticulum Stress
Hepatitis B virus
Hepatocellular Carcinoma
Hepatocytes
Cyclin A
28 引文 (Scopus)

Preparation of amino-acid-type selective isotope labeling of protein expressed in Pichia pastoris

Chen, C. Y., Cheng, C. H., Chen, Y. C., Lee, J. C., Chou, S. H., Huang, W. & Chuang, W. J., 2006 一月 1, 於 : Proteins: Structure, Function and Genetics. 62, 1, p. 279-287 9 p.

研究成果: Article

Isotope Labeling
Pichia
Isotopes
Labeling
Amino Acids
2005
98 引文 (Scopus)

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes

Wang, H. C., Chang, W. T., Chang, W. W., Wu, H. C., Huang, W., Lei, H. Y., Lai, M. D., Fausto, N. & Su, I. J., 2005 四月 1, 於 : Hepatology. 41, 4, p. 761-770 10 p.

研究成果: Article

Cyclin A
Hepatitis B virus
Hepatocytes
Up-Regulation
Endoplasmic Reticulum Stress
10 引文 (Scopus)

HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair

Hsieh, H. C., Hsieh, Y. H., Huang, Y. H., Shen, F. C., Tsai, H. N., Tsai, J. H., Lai, Y. T., Wang, Y. T., Chuang, W-J. & Huang, W-Y., 2005 九月 16, 於 : Biochemical and Biophysical Research Communications. 335, 1, p. 181-187 7 p.

研究成果: Article

Xeroderma Pigmentosum
Protein C
DNA Repair
Yeast
Saccharomyces cerevisiae
21 引文 (Scopus)

Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference

Cheng, T. L., Chang, W. W., Su, I. J., Lai, M-D., Huang, W-Y., Lei, H. Y. & Chang, W-T., 2005 十月 28, 於 : Biochemical and Biophysical Research Communications. 336, 3, p. 820-830 11 p.

研究成果: Article

Surface Antigens
Hepatitis B Surface Antigens
RNA Interference
Viruses
Hepatitis B virus