鄭 文義

Associate Research Fellow

  • 1141 引文
  • 18 h-指數
19992019
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研究成果 1999 2019

  • 1141 引文
  • 18 h-指數
  • 33 Article
  • 2 Letter
  • 1 Review article
篩選
Article
2019

Crystal Structures of the C-Terminally Truncated Endoglucanase Cel9Q from Clostridium thermocellum Complexed with Cellodextrins and Tris

Jeng, W. Y., Liu, C. I., Lu, T. J., Lin, H. J., Wang, N. C. & Wang, A. H. J., 2019 一月 18, 於 : ChemBioChem. 20, 2, p. 295-307 13 p.

研究成果: Article

Clostridium thermocellum
Cellobiose
Clostridium
Cellulase
Crystal structure
2017
3 引文 (Scopus)

Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease

Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 二月 1, 於 : Kidney international. 91, 2, p. 412-422 11 p.

研究成果: Article

Polycystic Kidney Diseases
Cysts
Kidney
Caspase 3
Transgenic Mice
2 引文 (Scopus)

The negative effects of KPN00353 on glycerol kinase and microaerobic 1,3-propanediol production in klebsiella pneumoniae

Jeng, W-Y., Panjaitan, N. S. D., Horng, Y. T., Chung, W. T., Chien, C. C. & Soo, P. C., 2017 十二月 7, 於 : Frontiers in Microbiology. 8, DEC, 2441.

研究成果: Article

Glycerol Kinase
Klebsiella pneumoniae
arginine glutamate
Glycerol
Phosphoenolpyruvate
2016

Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation

Kan, W. C., Lu, T. L., Ling, P., Lee, T. H., Cho, C. Y., Huang, C. Y. F., Jeng, W-Y., Weng, Y. P., Chiang, C. Y., Wu, J. B. & Lu, T. J., 2016 七月 1, 於 : Journal of Inorganic Biochemistry. 160, p. 33-39 7 p.

研究成果: Article

Phosphorylation
Phosphotransferases
Chemical activation
Yeast
Tyrosine
10 引文 (Scopus)

Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of Acinetobacter baumannii

Sun, J. R., Jeng, W-Y., Perng, C. L., Yang, Y. S., Soo, P. C., Chiang, Y. S. & Chiueh, T. S., 2016 六月 13, 於 : Journal of Antimicrobial Chemotherapy. 71, 6, p. 1488-1492 5 p.

研究成果: Article

Acinetobacter baumannii
Amino Acid Substitution
Operon
Microbial Drug Resistance
Site-Directed Mutagenesis
2015
8 引文 (Scopus)

Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin

Horng, Y. T., Jeng, W-Y., Chen, Y. Y., Liu, C. H., Dou, H. Y., Lee, J. J., Chang, K. C., Chien, C. C. & Soo, P. C., 2015 三月 1, 於 : Antimicrobial agents and chemotherapy. 59, 3, p. 1542-1548 7 p.

研究成果: Article

Rifampin
Mycobacterium tuberculosis
Codon
Genes
Mutation
29 引文 (Scopus)

Structural and functional roles of glycosylation in fungal laccase from lentinus sp.

Maestre-Reyna, M., Liu, W. C., Jeng, W-Y., Lee, C. C., Hsu, C. A., Wen, T. N., Wang, A. H. J. & Shyur, L. F., 2015 四月 7, 於 : PLoS ONE. 10, 4, e0120601.

研究成果: Article

Lentinula
Lentinus
Glycosylation
Laccase
laccase
2014
29 引文 (Scopus)

Crowning proteins: Modulating the protein surface properties using crown ethers

Lee, C. C., Maestre-Reyna, M., Hsu, K. C., Wang, H. C., Liu, C. I., Jeng, W-Y., Lin, L. L., Wood, R., Chou, C. C., Yang, J. M. & Wang, A. H. J., 2014 十一月 24, 於 : Angewandte Chemie - International Edition. 53, 48, p. 13054-13058 5 p.

研究成果: Article

Crown Ethers
Crown ethers
Surface properties
Proteins
Membrane Proteins
9 引文 (Scopus)

ManA is regulated by RssAB signaling and promotes motility in Serratia marcescens

Soo, P. C., Horng, Y. T., Chang, Y. L., Tsai, W. W., Jeng, W-Y., Lu, C. C. & Lai, H. C., 2014 一月 1, 於 : Research in Microbiology. 165, 1, p. 21-29 9 p.

研究成果: Article

Serratia marcescens
Serratia
Mannose-6-Phosphate Isomerase
Surface Tension
Electrophoretic Mobility Shift Assay
9 引文 (Scopus)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

Yang, H. C., Chuang, J. Y., Jeng, W-Y., Liu, C. I., Wang, A. H. J., Lu, P-J., Chang, W. C. & Hung, J-J., 2014 十二月 16, 於 : Nucleic acids research. 42, 22, p. 13573-13587 15 p.

研究成果: Article

Mitosis
Phosphorylation
DNA
Peptides
Cell Cycle
23 引文 (Scopus)

Structural insights into the catalytic mechanism of human squalene synthase

Liu, C. I., Jeng, W-Y., Chang, W. J., Shih, M. F., Ko, T. P. & Wang, A. H. J., 2014 二月 1, 於 : Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 231-241 11 p.

研究成果: Article

Farnesyl-Diphosphate Farnesyltransferase
Niacinamide
Biosynthetic Pathways
Phosphates
Squalene
2012
24 引文 (Scopus)

Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase

Liu, C. I., Jeng, W. Y., Chang, W. J., Ko, T. P. & Wang, A. H. J., 2012 五月 25, 於 : Journal of Biological Chemistry. 287, 22, p. 18750-18757 8 p.

研究成果: Article

Farnesyl-Diphosphate Farnesyltransferase
Oxidative stress
Sterols
Enzymes
Metabolites
5 引文 (Scopus)

Engineering of dual-functional hybrid glucanases

Liu, W. C., Lin, Y. S., Jeng, W. Y., Chen, J. H., Wang, A. H. J. & Shyur, L. F., 2012 十一月 1, 於 : Protein Engineering, Design and Selection. 25, 11, p. 771-780 10 p.

研究成果: Article

Enzymes
Industrial applications
Fibrobacter
Genes
Thermotoga maritima
4 引文 (Scopus)

Functional Studies of ssDNA Binding Ability of MarR Family Protein TcaR from Staphylococcus epidermidis

Chang, Y. M., Chen, C. K. M., Chang, Y. C., Jeng, W-Y., Hou, M. H. & Wang, A. H. J., 2012 九月 21, 於 : PloS one. 7, 9, e45665.

研究成果: Article

single-stranded DNA
Staphylococcus epidermidis
Single-Stranded DNA
binding capacity
Microbial Drug Resistance
21 引文 (Scopus)
Glucosidases
HEPES
Opipramol
Glucose
Oligosaccharides
48 引文 (Scopus)

Mutations in the substrate entrance region of β-glucosidase from Trichoderma reesei improve enzyme activity and thermostability

Lee, H. L., Chang, C. K., Jeng, W-Y., Wang, A. H. J. & Liang, P. H., 2012 十一月 1, 於 : Protein Engineering, Design and Selection. 25, 11, p. 733-740 8 p.

研究成果: Article

Glucosidases
Trichoderma
Enzyme activity
Cellobiose
Mutation
2011
20 引文 (Scopus)
Thermotoga maritima
Cellulases
Catalytic Domain
Crystal structure
Glucans
106 引文 (Scopus)

Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis

Jeng, W. Y., Wang, N. C., Lin, M. H., Lin, C. T., Liaw, Y. C., Chang, W. J., Liu, C. I., Liang, P. H. & Wang, A. H. J., 2011 一月 1, 於 : Journal of Structural Biology. 173, 1, p. 46-56 11 p.

研究成果: Article

Clostridium cellulovorans
Glucosidases
Isoptera
Trichoderma
Fungi
2010
46 引文 (Scopus)

Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry

Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W-Y., Wang, A. H. J., Wu, C. Y. & Wong, C. H., 2010 九月 29, 於 : Journal of the American Chemical Society. 132, 38, p. 13371-13380 10 p.

研究成果: Article

Organophosphonates
Aluminum Oxide
Glass
Polysaccharides
Aluminum
42 引文 (Scopus)

Mechanism of action and inhibition of dehydrosqualene synthase

Lin, F. Y., Liu, C. I., Liu, Y. L., Zhang, Y., Wang, K., Jeng, W-Y., Ko, T. P., Cao, R., Wang, A. H. J. & Oldfield, E., 2010 十二月 14, 於 : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21337-21342 6 p.

研究成果: Article

Diphosphates
Terpenes
Alkenes
Sterols
Carotenoids
50 引文 (Scopus)

Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis

Chang, Y. M., Jeng, W-Y., Ko, T. P., Yeh, Y. J., Chen, C. K. M. & Wang, A. H. J., 2010 五月 11, 於 : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8617-8622 6 p.

研究成果: Article

Staphylococcus epidermidis
Iron-Dextran Complex
Biofilms
Salicylates
Anti-Bacterial Agents
16 引文 (Scopus)

Structures of human MST3 kinase in complex with adenine, ADP and Mn 2+

Ko, T. P., Jeng, W-Y., Liu, C. I., Lai, M-D., Wu, C. L., Chang, W. J., Shr, H. L., Lu, T. J. & Wang, A. H. J., 2010 二月 17, 於 : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 145-154 10 p.

研究成果: Article

Adenine
Adenosine Diphosphate
Catalytic Domain
Phosphotransferases
Ligands
2009
8 引文 (Scopus)
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
55 引文 (Scopus)

Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: In vitro, in vivo, and crystallographic results

Song, Y., Liu, C. I., Lin, F. Y., Joo, H. N., Hensler, M., Liu, Y. L., Jeng, W-Y., Low, J., Liu, G. Y., Nizet, V., Wang, A. H. J. & Oldfield, E., 2009 七月 9, 於 : Journal of Medicinal Chemistry. 52, 13, p. 3869-3880 12 p.

研究成果: Article

Virulence Factors
Staphylococcus aureus
Carotenoids
Gold
Inhibitory Concentration 50
2008
264 引文 (Scopus)

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

Liu, C. I., Liu, G. Y., Song, Y., Yin, F., Hensler, M. E., Jeng, W-Y., Nizet, V., Wang, A. H. J. & Oldfield, E., 2008 三月 7, 於 : Science. 319, 5868, p. 1391-1394 4 p.

研究成果: Article

Anticholesteremic Agents
Virulence
Staphylococcus aureus
Farnesyl-Diphosphate Farnesyltransferase
Cholesterol
36 引文 (Scopus)

Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in staphylococcus epidermidis

Jeng, W-Y., Ko, T. P., Liu, C. I., Guo, R. T., Liu, C. L., Shr, H. L. & Wang, A. H. J., 2008 三月 1, 於 : Nucleic acids research. 36, 5, p. 1567-1577 11 p.

研究成果: Article

Iron-Dextran Complex
Staphylococcus epidermidis
Biofilms
DNA
Repressor Proteins
2007
120 引文 (Scopus)

Bisphosphonates target multiple sites in both cis- and trans- prenyltransferases

Guo, R. T., Cao, R., Liang, P. H., Ko, T. P., Chang, T. H., Hudock, M. P., Jeng, W-Y., Chen, C. K. M., Zhang, Y., Song, Y., Kuo, C. J., Yin, F., Oldfield, E. & Wang, A. H. J., 2007 六月 12, 於 : Proceedings of the National Academy of Sciences of the United States of America. 104, 24, p. 10022-10027 6 p.

研究成果: Article

undecaprenyl pyrophosphate synthetase
Diphosphonates
Farnesyltranstransferase
Geranyltranstransferase
Binding Sites
2005
16 引文 (Scopus)

Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3

Lu, T. J., Huang, C. Y. F., Yuan, C. J., Lee, Y. C., Leu, T-H., Chang, W. C., Lu, T. L., Jeng, W-Y. & Lai, M-D., 2005 六月 1, 於 : Journal of Inorganic Biochemistry. 99, 6, p. 1306-1313 8 p.

研究成果: Article

Protein-Serine-Threonine Kinases
Zinc
Phosphotransferases
Ions
Metal ions
2004
12 引文 (Scopus)

The catalase activity of Nα-acetyl-microperoxidase-8

Jeng, W-Y., Tsai, Y. H. & Chuang, W-J., 2004 九月 1, 於 : Journal of Peptide Research. 64, 3, p. 104-109 6 p.

研究成果: Article

Catalase
Cytochrome P-450 Enzyme System
Peroxidase
Oxygen
Ligands
2003
49 引文 (Scopus)

Maturation processing and characterization of streptopain

Chen, C. Y., Luo, S. C., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Jeng, W. Y. & Chuang, W. J., 2003 五月 9, 於 : Journal of Biological Chemistry. 278, 19, p. 17336-17343 8 p.

研究成果: Article

streptopain
Exotoxins
Enzyme Precursors
Processing
Cysteine Proteases
2002
29 引文 (Scopus)
Cytochromes c
Escherichia coli
Horses
Hemeproteins
Oxidation-Reduction
18 引文 (Scopus)

Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)

Liu, P. P., Chen, Y. C., Li, C., Hsieh, Y. H., Chen, S. W., Chen, S. H., Jeng, W. Y. & Chuang, W. J., 2002 十二月 1, 於 : Proteins: Structure, Function and Genetics. 49, 4, p. 543-553 11 p.

研究成果: Article

Interleukins
DNA
Interleukin-2
Forkhead Transcription Factors
Gene expression
1999
10 引文 (Scopus)
Kinetics
Porphyrins
Circular Dichroism
microperoxidase
Peroxidase