每年研究成果
研究成果 1999 2019
2019
Crystal Structures of the C-Terminally Truncated Endoglucanase Cel9Q from Clostridium thermocellum Complexed with Cellodextrins and Tris
Jeng, W. Y., Liu, C. I., Lu, T. J., Lin, H. J., Wang, N. C. & Wang, A. H. J., 2019 一月 18, 於 : ChemBioChem. 20, 2, p. 295-307 13 p.研究成果: Article
Clostridium thermocellum
Cellobiose
Clostridium
Cellulase
Crystal structure
2017
3
引文
(Scopus)
Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease
Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 二月 1, 於 : Kidney international. 91, 2, p. 412-422 11 p.研究成果: Article
Polycystic Kidney Diseases
Cysts
Kidney
Caspase 3
Transgenic Mice
2
引文
(Scopus)
The negative effects of KPN00353 on glycerol kinase and microaerobic 1,3-propanediol production in klebsiella pneumoniae
Jeng, W-Y., Panjaitan, N. S. D., Horng, Y. T., Chung, W. T., Chien, C. C. & Soo, P. C., 2017 十二月 7, 於 : Frontiers in Microbiology. 8, DEC, 2441.研究成果: Article
Glycerol Kinase
Klebsiella pneumoniae
arginine glutamate
Glycerol
Phosphoenolpyruvate
2016
Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation
Kan, W. C., Lu, T. L., Ling, P., Lee, T. H., Cho, C. Y., Huang, C. Y. F., Jeng, W-Y., Weng, Y. P., Chiang, C. Y., Wu, J. B. & Lu, T. J., 2016 七月 1, 於 : Journal of Inorganic Biochemistry. 160, p. 33-39 7 p.研究成果: Article
Phosphorylation
Phosphotransferases
Chemical activation
Yeast
Tyrosine
10
引文
(Scopus)
Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of Acinetobacter baumannii
Sun, J. R., Jeng, W-Y., Perng, C. L., Yang, Y. S., Soo, P. C., Chiang, Y. S. & Chiueh, T. S., 2016 六月 13, 於 : Journal of Antimicrobial Chemotherapy. 71, 6, p. 1488-1492 5 p.研究成果: Article
Acinetobacter baumannii
Amino Acid Substitution
Operon
Microbial Drug Resistance
Site-Directed Mutagenesis
2015
8
引文
(Scopus)
Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin
Horng, Y. T., Jeng, W-Y., Chen, Y. Y., Liu, C. H., Dou, H. Y., Lee, J. J., Chang, K. C., Chien, C. C. & Soo, P. C., 2015 三月 1, 於 : Antimicrobial agents and chemotherapy. 59, 3, p. 1542-1548 7 p.研究成果: Article
Rifampin
Mycobacterium tuberculosis
Codon
Genes
Mutation
29
引文
(Scopus)
Structural and functional roles of glycosylation in fungal laccase from lentinus sp.
Maestre-Reyna, M., Liu, W. C., Jeng, W-Y., Lee, C. C., Hsu, C. A., Wen, T. N., Wang, A. H. J. & Shyur, L. F., 2015 四月 7, 於 : PLoS ONE. 10, 4, e0120601.研究成果: Article
Lentinula
Lentinus
Glycosylation
Laccase
laccase
2014
29
引文
(Scopus)
Crowning proteins: Modulating the protein surface properties using crown ethers
Lee, C. C., Maestre-Reyna, M., Hsu, K. C., Wang, H. C., Liu, C. I., Jeng, W-Y., Lin, L. L., Wood, R., Chou, C. C., Yang, J. M. & Wang, A. H. J., 2014 十一月 24, 於 : Angewandte Chemie - International Edition. 53, 48, p. 13054-13058 5 p.研究成果: Article
Crown Ethers
Crown ethers
Surface properties
Proteins
Membrane Proteins
9
引文
(Scopus)
ManA is regulated by RssAB signaling and promotes motility in Serratia marcescens
Soo, P. C., Horng, Y. T., Chang, Y. L., Tsai, W. W., Jeng, W-Y., Lu, C. C. & Lai, H. C., 2014 一月 1, 於 : Research in Microbiology. 165, 1, p. 21-29 9 p.研究成果: Article
Serratia marcescens
Serratia
Mannose-6-Phosphate Isomerase
Surface Tension
Electrophoretic Mobility Shift Assay
9
引文
(Scopus)
Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis
Yang, H. C., Chuang, J. Y., Jeng, W-Y., Liu, C. I., Wang, A. H. J., Lu, P-J., Chang, W. C. & Hung, J-J., 2014 十二月 16, 於 : Nucleic acids research. 42, 22, p. 13573-13587 15 p.研究成果: Article
Mitosis
Phosphorylation
DNA
Peptides
Cell Cycle
23
引文
(Scopus)
Structural insights into the catalytic mechanism of human squalene synthase
Liu, C. I., Jeng, W-Y., Chang, W. J., Shih, M. F., Ko, T. P. & Wang, A. H. J., 2014 二月 1, 於 : Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 231-241 11 p.研究成果: Article
Farnesyl-Diphosphate Farnesyltransferase
Niacinamide
Biosynthetic Pathways
Phosphates
Squalene
2012
24
引文
(Scopus)
Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
Liu, C. I., Jeng, W. Y., Chang, W. J., Ko, T. P. & Wang, A. H. J., 2012 五月 25, 於 : Journal of Biological Chemistry. 287, 22, p. 18750-18757 8 p.研究成果: Article
Farnesyl-Diphosphate Farnesyltransferase
Oxidative stress
Sterols
Enzymes
Metabolites
5
引文
(Scopus)
Engineering of dual-functional hybrid glucanases
Liu, W. C., Lin, Y. S., Jeng, W. Y., Chen, J. H., Wang, A. H. J. & Shyur, L. F., 2012 十一月 1, 於 : Protein Engineering, Design and Selection. 25, 11, p. 771-780 10 p.研究成果: Article
Enzymes
Industrial applications
Fibrobacter
Genes
Thermotoga maritima
4
引文
(Scopus)
Functional Studies of ssDNA Binding Ability of MarR Family Protein TcaR from Staphylococcus epidermidis
Chang, Y. M., Chen, C. K. M., Chang, Y. C., Jeng, W-Y., Hou, M. H. & Wang, A. H. J., 2012 九月 21, 於 : PloS one. 7, 9, e45665.研究成果: Article
single-stranded DNA
Staphylococcus epidermidis
Single-Stranded DNA
binding capacity
Microbial Drug Resistance
21
引文
(Scopus)
High-resolution structures of Neotermes koshunensis β-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates
Jeng, W-Y., Wang, N. C., Lin, C. T., Chang, W. J., Liu, C. I. & Wang, A. H. J., 2012 七月 1, 於 : Acta Crystallographica Section D: Biological Crystallography. 68, 7, p. 829-838 10 p.研究成果: Article
Glucosidases
HEPES
Opipramol
Glucose
Oligosaccharides
48
引文
(Scopus)
Mutations in the substrate entrance region of β-glucosidase from Trichoderma reesei improve enzyme activity and thermostability
Lee, H. L., Chang, C. K., Jeng, W-Y., Wang, A. H. J. & Liang, P. H., 2012 十一月 1, 於 : Protein Engineering, Design and Selection. 25, 11, p. 733-740 8 p.研究成果: Article
Glucosidases
Trichoderma
Enzyme activity
Cellobiose
Mutation
2011
20
引文
(Scopus)
Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: Essential residues for β-1,3- and β-1,4-glucan selection
Jeng, W-Y., Wang, N. C., Lin, C. T., Shyur, L. F. & Wang, A. H. J., 2011 十二月 30, 於 : Journal of Biological Chemistry. 286, 52, p. 45030-45040 11 p.研究成果: Article
Thermotoga maritima
Cellulases
Catalytic Domain
Crystal structure
Glucans
106
引文
(Scopus)
Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis
Jeng, W. Y., Wang, N. C., Lin, M. H., Lin, C. T., Liaw, Y. C., Chang, W. J., Liu, C. I., Liang, P. H. & Wang, A. H. J., 2011 一月 1, 於 : Journal of Structural Biology. 173, 1, p. 46-56 11 p.研究成果: Article
Clostridium cellulovorans
Glucosidases
Isoptera
Trichoderma
Fungi
2010
46
引文
(Scopus)
Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry
Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W-Y., Wang, A. H. J., Wu, C. Y. & Wong, C. H., 2010 九月 29, 於 : Journal of the American Chemical Society. 132, 38, p. 13371-13380 10 p.研究成果: Article
Organophosphonates
Aluminum Oxide
Glass
Polysaccharides
Aluminum
42
引文
(Scopus)
Mechanism of action and inhibition of dehydrosqualene synthase
Lin, F. Y., Liu, C. I., Liu, Y. L., Zhang, Y., Wang, K., Jeng, W-Y., Ko, T. P., Cao, R., Wang, A. H. J. & Oldfield, E., 2010 十二月 14, 於 : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21337-21342 6 p.研究成果: Article
Diphosphates
Terpenes
Alkenes
Sterols
Carotenoids
50
引文
(Scopus)
Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis
Chang, Y. M., Jeng, W-Y., Ko, T. P., Yeh, Y. J., Chen, C. K. M. & Wang, A. H. J., 2010 五月 11, 於 : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8617-8622 6 p.研究成果: Article
Staphylococcus epidermidis
Iron-Dextran Complex
Biofilms
Salicylates
Anti-Bacterial Agents
16
引文
(Scopus)
Structures of human MST3 kinase in complex with adenine, ADP and Mn 2+
Ko, T. P., Jeng, W-Y., Liu, C. I., Lai, M-D., Wu, C. L., Chang, W. J., Shr, H. L., Lu, T. J. & Wang, A. H. J., 2010 二月 17, 於 : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 145-154 10 p.研究成果: Article
Adenine
Adenosine Diphosphate
Catalytic Domain
Phosphotransferases
Ligands
2009
8
引文
(Scopus)
Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin
Chen, C. Y., Shiu, J. H., Hsieh, Y. H., Liu, Y. C., Chen, Y. C., Chen, Y. C., Jeng, W. Y., Tang, M. J., Lo, S. J. & Chuang, W. J., 2009 九月 1, 於 : Proteins: Structure, Function and Bioinformatics. 76, 4, p. 808-821 14 p.研究成果: Article
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
55
引文
(Scopus)
Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: In vitro, in vivo, and crystallographic results
Song, Y., Liu, C. I., Lin, F. Y., Joo, H. N., Hensler, M., Liu, Y. L., Jeng, W-Y., Low, J., Liu, G. Y., Nizet, V., Wang, A. H. J. & Oldfield, E., 2009 七月 9, 於 : Journal of Medicinal Chemistry. 52, 13, p. 3869-3880 12 p.研究成果: Article
Virulence Factors
Staphylococcus aureus
Carotenoids
Gold
Inhibitory Concentration 50
2008
264
引文
(Scopus)
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence
Liu, C. I., Liu, G. Y., Song, Y., Yin, F., Hensler, M. E., Jeng, W-Y., Nizet, V., Wang, A. H. J. & Oldfield, E., 2008 三月 7, 於 : Science. 319, 5868, p. 1391-1394 4 p.研究成果: Article
Anticholesteremic Agents
Virulence
Staphylococcus aureus
Farnesyl-Diphosphate Farnesyltransferase
Cholesterol
36
引文
(Scopus)
Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in staphylococcus epidermidis
Jeng, W-Y., Ko, T. P., Liu, C. I., Guo, R. T., Liu, C. L., Shr, H. L. & Wang, A. H. J., 2008 三月 1, 於 : Nucleic acids research. 36, 5, p. 1567-1577 11 p.研究成果: Article
Iron-Dextran Complex
Staphylococcus epidermidis
Biofilms
DNA
Repressor Proteins
2007
120
引文
(Scopus)
Bisphosphonates target multiple sites in both cis- and trans- prenyltransferases
Guo, R. T., Cao, R., Liang, P. H., Ko, T. P., Chang, T. H., Hudock, M. P., Jeng, W-Y., Chen, C. K. M., Zhang, Y., Song, Y., Kuo, C. J., Yin, F., Oldfield, E. & Wang, A. H. J., 2007 六月 12, 於 : Proceedings of the National Academy of Sciences of the United States of America. 104, 24, p. 10022-10027 6 p.研究成果: Article
undecaprenyl pyrophosphate synthetase
Diphosphonates
Farnesyltranstransferase
Geranyltranstransferase
Binding Sites
2005
16
引文
(Scopus)
Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3
Lu, T. J., Huang, C. Y. F., Yuan, C. J., Lee, Y. C., Leu, T-H., Chang, W. C., Lu, T. L., Jeng, W-Y. & Lai, M-D., 2005 六月 1, 於 : Journal of Inorganic Biochemistry. 99, 6, p. 1306-1313 8 p.研究成果: Article
Protein-Serine-Threonine Kinases
Zinc
Phosphotransferases
Ions
Metal ions
2004
12
引文
(Scopus)
The catalase activity of Nα-acetyl-microperoxidase-8
Jeng, W-Y., Tsai, Y. H. & Chuang, W-J., 2004 九月 1, 於 : Journal of Peptide Research. 64, 3, p. 104-109 6 p.研究成果: Article
Catalase
Cytochrome P-450 Enzyme System
Peroxidase
Oxygen
Ligands
2003
49
引文
(Scopus)
Maturation processing and characterization of streptopain
Chen, C. Y., Luo, S. C., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Jeng, W. Y. & Chuang, W. J., 2003 五月 9, 於 : Journal of Biological Chemistry. 278, 19, p. 17336-17343 8 p.研究成果: Article
streptopain
Exotoxins
Enzyme Precursors
Processing
Cysteine Proteases
2002
29
引文
(Scopus)
Expression and characterization of recombinant human cytochrome c in E. coli
Jeng, W. Y., Chen, C. Y., Chang, H. C. & Chuang, W. J., 2002 十二月 1, 於 : Journal of Bioenergetics and Biomembranes. 34, 6, p. 423-431 9 p.研究成果: Article
Cytochromes c
Escherichia coli
Horses
Hemeproteins
Oxidation-Reduction
18
引文
(Scopus)
Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)
Liu, P. P., Chen, Y. C., Li, C., Hsieh, Y. H., Chen, S. W., Chen, S. H., Jeng, W. Y. & Chuang, W. J., 2002 十二月 1, 於 : Proteins: Structure, Function and Genetics. 49, 4, p. 543-553 11 p.研究成果: Article
Interleukins
DNA
Interleukin-2
Forkhead Transcription Factors
Gene expression
1999
10
引文
(Scopus)
Kinetic and structural studies of N-acetyl-microperoxidase-5 and - microperoxidase-8
Chuang, W-J., Chang, Y. D. & Jeng, W-Y., 1999 六月 15, 於 : Journal of Inorganic Biochemistry. 75, 2, p. 93-97 5 p.研究成果: Article
Kinetics
Porphyrins
Circular Dichroism
microperoxidase
Peroxidase