• 1734 引文
  • 25 h-指數
1988 …2019

每年研究成果

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研究成果

2019

A novel αiIbβ3 antagonist from snake venom prevents thrombosis without causing bleeding

Kuo, Y. J., Chung, C. H., Pan, T. Y., Chuang, W. J. & Huang, T. F., 2019 十二月 21, 於 : Toxins. 12, 1, 11.

研究成果: Article

開啟存取
1 引文 斯高帕斯(Scopus)
2017

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 四月, 於 : PloS one. 12, 4, e0175321.

研究成果: Article

3 引文 斯高帕斯(Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 一月 1, 於 : European Journal of Pharmacology. 804, p. 94-101 8 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)
2016
3 引文 斯高帕斯(Scopus)

Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αiIbβ3 antagonist, disintegrin

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 七月 1, 於 : Thrombosis Research. 143, p. 3-10 8 p.

研究成果: Article

4 引文 斯高帕斯(Scopus)

Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 三月 18, 於 : Scientific reports. 6, 23387.

研究成果: Article

6 引文 斯高帕斯(Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., 2016 五月 16, 於 : Scientific reports. 6, 26026.

研究成果: Article

1 引文 斯高帕斯(Scopus)
2015

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S. Y., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2015 十二月 1, 於 : PloS one. 10, 12, e0145223.

研究成果: Article

2 引文 斯高帕斯(Scopus)

Role of spinal CXCL1 (GROα) in opioid tolerance a human-to-rodent translational study

Lin, C. P., Kang, K. H., Lin, T. H., Wu, M. Y., Liou, H. C., Chuang, W. J., Sun, W. Z. & Fu, W. M., 2015 三月 4, 於 : Anesthesiology. 122, 3, p. 666-676 11 p.

研究成果: Article

15 引文 斯高帕斯(Scopus)
2014
4 引文 斯高帕斯(Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y. S., Chuang, W. J., Wu, J. J. & Wang, S., 2014 二月 21, 於 : PloS one. 9, 2, e89027.

研究成果: Article

9 引文 斯高帕斯(Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 一月 1, 於 : Pathogens and Disease. 70, 2, p. 194-201 8 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Type i and II β-turns prediction using NMR chemical shifts

Wang, C. C., Lai, W. C. & Chuang, W. J., 2014 七月, 於 : Journal of Biomolecular NMR. 59, 3, p. 175-184 10 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)

人類纖維黏蛋白變異體及其醫藥用途

Chuang, W-J., 2014 四月 1, 專利號 I580692

研究成果: Patent

2013
13 引文 斯高帕斯(Scopus)

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

貢獻的翻譯標題: 去整合蛋白變異體及其醫藥用途Chuang, W-J., 2013 三月 28, 專利號 HK1136160

研究成果: Patent

Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection

Lu, S. L., Tsai, C. Y., Luo, Y. H., Kuo, C. F., Lin, W. C., Chang, Y. T., Wu, J. J., Chuang, W. J., Liu, C. C., Chao, L., Chao, J. & Lin, Y. S., 2013 十一月 1, 於 : Antimicrobial agents and chemotherapy. 57, 11, p. 5366-5372 7 p.

研究成果: Article

28 引文 斯高帕斯(Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 十二月 3, 於 : PloS one. 8, 12, e81882.

研究成果: Article

11 引文 斯高帕斯(Scopus)

Streptopain

Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C. & Lin, M. T., 2013 八月 29, Handbook of Proteolytic Enzymes. Elsevier Ltd, 卷 2. p. 2142-2150 9 p.

研究成果: Chapter

Upregulation of drug transporter expression by osteopontin in prostate cancer cellss

Hsieh, I. S., Huang, W. H., Liou, H. C., Chuang, W-J., Yang, R. S. & Fu, W. M., 2013 五月 1, 於 : Molecular Pharmacology. 83, 5, p. 968-977 10 p.

研究成果: Article

26 引文 斯高帕斯(Scopus)

Zinc-dependent interaction between JAB1 and Pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis

Hsu, J. L., Chuang, W. J., Su, I. J., Gui, W. J., Chang, Y. Y., Lee, Y. P., Ai, Y. L., Chuang, D. T. & Huang, W., 2013 十二月 1, 於 : Journal of Virology. 87, 23, p. 12675-12684 10 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)
2012

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2012 三月 30, 專利號 577998

研究成果: Patent

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2012 三月 30, 專利號 598176

研究成果: Patent

Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition

Cheng, C. H., Chen, Y. C., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Chen, C. Y. & Chuang, W. J., 2012 十二月 1, 於 : Protein Science. 21, 12, p. 1872-1884 13 p.

研究成果: Article

3 引文 斯高帕斯(Scopus)
9 引文 斯高帕斯(Scopus)
9 引文 斯高帕斯(Scopus)

Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin

Chen, Y. C., Cheng, C. H., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Lee, J. C. & Chuang, W. J., 2012 十二月 5, 於 : Toxicon. 60, 8, p. 1342-1348 7 p.

研究成果: Article

6 引文 斯高帕斯(Scopus)

Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of KV1.3 Channel Blockers

Anangi, R., Koshy, S., Huq, R., Beeton, C., Chuang, W. J. & King, G. F., 2012 十二月 29, 於 : PloS one. 7, 12, e52965.

研究成果: Article

10 引文 斯高帕斯(Scopus)
2011

COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANGIOGENESIS-RELATED EYE DISEASES

貢獻的翻譯標題: 治療血管新生相關之眼疾之組合物及方法Chuang, W-J., 2011 十一月 16, 專利號 I581801

研究成果: Patent

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2011 二月 10, 專利號 2477727

研究成果: Patent

Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan

Chiang-Ni, C., Wu, A. B., Liu, C. C., Chen, K. T., Lin, Y. S., Chuang, W. J., Fang, H. Y. & Wu, J. J., 2011 十二月 1, 於 : Journal of Microbiology, Immunology and Infection. 44, 6, p. 424-429 6 p.

研究成果: Article

14 引文 斯高帕斯(Scopus)
7 引文 斯高帕斯(Scopus)

Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway

Hsu, C. C., Chuang, W-J., Chang, C. H., Tseng, Y. L., Peng, H. C. & Huang, T. F., 2011 三月 1, 於 : Journal of Thrombosis and Haemostasis. 9, 3, p. 593-602 10 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)

POLYPEPTIDES SELECTIVE FOR αVβ3 INTEGRIN CONJUGATED WITH A VARIANT OF HUMAN SERUM ALBUMIN (HSA) AND PHARMACEUTICAL USES THEREOF

貢獻的翻譯標題: 具αvβ3整合蛋白選擇性且與人類血清白蛋白(HSA)變體結合之多?及其於醫藥上之用途Chuang, W-J., 2011 三月 1, 專利號 I557224

研究成果: Patent

18 引文 斯高帕斯(Scopus)
8 引文 斯高帕斯(Scopus)
2010

Agaricus blazei Murill ameliorates myocardial ischemia-reperfusion injury

Huang, C. H., Tsai, H. N., Peng, R. H., Hsieh, Y. H., Chuang, W-J., Hsu, G. C., Huang, W-Y. & Chen, W. J., 2010 十二月 1, 於 : Acta Cardiologica Sinica. 26, 4, p. 235-241 7 p.

研究成果: Article

4 引文 斯高帕斯(Scopus)

Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3

Anangi, R., Chen, C. C., Lin, Y. W., Cheng, Y. R., Cheng, C. H., Chen, Y. C., Chu, Y. P. & Chuang, W. J., 2010 十二月 1, 於 : Toxicon. 56, 8, p. 1388-1397 10 p.

研究成果: Article

14 引文 斯高帕斯(Scopus)
15 引文 斯高帕斯(Scopus)

Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2010 四月 1, 於 : International Journal of Medical Microbiology. 300, 4, p. 259-264 6 p.

研究成果: Article

20 引文 斯高帕斯(Scopus)
2009
12 引文 斯高帕斯(Scopus)

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2009 十月 13, 專利號 291711

研究成果: Patent

Disintegrin variants and pharmaceutical uses thereof

Chuang, W-J., 2009 七月 29, 專利號 153383

研究成果: Patent

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

貢獻的翻譯標題: 去整合蛋白變異體及其醫藥用途Chuang, W-J., 2009 十二月 2, 專利號 EP 2124548

研究成果: Patent

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

貢獻的翻譯標題: 去整合蛋白變異體及其醫藥用途Chuang, W-J., 2009 七月 23, 專利號 60/871,854

研究成果: Patent

8 引文 斯高帕斯(Scopus)
14 引文 斯高帕斯(Scopus)

Procaspase 8 and bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin B-induced apoptosis

Chang, C. W., Tsai, W. H., Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2009 十一月 27, 於 : Journal of Biological Chemistry. 284, 48, p. 33195-33205 11 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Huang, W. & Chuang, W. J., 2009 四月 17, 於 : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)