• 1696 引文
  • 24 h-指數
1988 …2020
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研究成果 1988 2017

篩選
Article
2017
2 引文 (Scopus)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 四月, 於 : PloS one. 12, 4, e0175321.

研究成果: Article

integrins
Integrins
Platelets
Disintegrins
mutants
5 引文 (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 一月 1, 於 : European Journal of Pharmacology. 804, p. 94-101 8 p.

研究成果: Article

Osteoclasts
Integrins
Osteoporosis
Bone Resorption
Osteogenesis
2016
2 引文 (Scopus)
Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
3 引文 (Scopus)

Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αiIbβ3 antagonist, disintegrin

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 七月 1, 於 : Thrombosis Research. 143, p. 3-10 8 p.

研究成果: Article

Disintegrins
Hemorrhage
Half-Life
Platelet Aggregation
rhodostomin
Chemical shift
Oxidation-Reduction
Cysteine
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
5 引文 (Scopus)

Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade

Hsu, C. C., Chuang, W. J., Chung, C. H., Chang, C. H., Peng, H. C. & Huang, T. F., 2016 三月 18, 於 : Scientific reports. 6, 23387.

研究成果: Article

Integrin alphaVbeta3
Disintegrins
Snake Venoms
Toll-Like Receptors
Sepsis
1 引文 (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., 2016 五月 16, 於 : Scientific reports. 6, 26026.

研究成果: Article

Protein S
Macrophages
streptopain
Streptococcus
Phagocytosis
2015
1 引文 (Scopus)

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S. Y., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2015 十二月 1, 於 : PloS one. 10, 12, e0145223.

研究成果: Article

Clustered Regularly Interspaced Short Palindromic Repeats
Streptococcus
molecular epidemiology
loci
nucleic acids
15 引文 (Scopus)

Role of spinal CXCL1 (GROα) in opioid tolerance a human-to-rodent translational study

Lin, C. P., Kang, K. H., Lin, T. H., Wu, M. Y., Liou, H. C., Chuang, W. J., Sun, W. Z. & Fu, W. M., 2015 三月 4, 於 : Anesthesiology. 122, 3, p. 666-676 11 p.

研究成果: Article

Opioid Analgesics
Rodentia
Morphine
Cerebrospinal Fluid
Chemokines
2014
3 引文 (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Erythromycin
Streptococcus
Nucleic Acids
Streptococcus pyogenes
9 引文 (Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y. S., Chuang, W. J., Wu, J. J. & Wang, S., 2014 二月 21, 於 : PloS one. 9, 2, e89027.

研究成果: Article

Streptococcus
Peroxides
peroxides
DNA
X ray scattering
5 引文 (Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 一月 1, 於 : Pathogens and Disease. 70, 2, p. 194-201 8 p.

研究成果: Article

Streptococcus
Capsules
DNA
Growth
Virulence
2 引文 (Scopus)

Type i and II β-turns prediction using NMR chemical shifts

Wang, C. C., Lai, W. C. & Chuang, W-J., 2014 一月 1, 於 : Journal of Biomolecular NMR. 59, 3, p. 175-184 10 p.

研究成果: Article

Chemical shift
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Secondary Protein Structure
Cluster Analysis
2013
12 引文 (Scopus)
Necrotizing Fasciitis
Streptococcus pyogenes
Pandemics
Genome
24 引文 (Scopus)

Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection

Lu, S. L., Tsai, C. Y., Luo, Y. H., Kuo, C. F., Lin, W. C., Chang, Y. T., Wu, J. J., Chuang, W. J., Liu, C. C., Chao, L., Chao, J. & Lin, Y. S., 2013 十一月 1, 於 : Antimicrobial agents and chemotherapy. 57, 11, p. 5366-5372 7 p.

研究成果: Article

Streptococcal Infections
Anti-Inflammatory Agents
Streptococcus
Infection
kallistatin
11 引文 (Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 十二月 3, 於 : PloS one. 8, 12, e81882.

研究成果: Article

deoxyribonucleases
Bacteriophages
Oxidative stress
Deoxyribonucleases
Streptococcus
26 引文 (Scopus)

Upregulation of drug transporter expression by osteopontin in prostate cancer cellss

Hsieh, I. S., Huang, W. H., Liou, H. C., Chuang, W-J., Yang, R. S. & Fu, W. M., 2013 五月 1, 於 : Molecular Pharmacology. 83, 5, p. 968-977 10 p.

研究成果: Article

Osteopontin
Prostatic Neoplasms
Up-Regulation
Daunorubicin
Pharmaceutical Preparations
2 引文 (Scopus)

Zinc-dependent interaction between JAB1 and Pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis

Hsu, J. L., Chuang, W. J., Su, I. J., Gui, W. J., Chang, Y. Y., Lee, Y. P., Ai, Y. L., Chuang, D. T. & Huang, W., 2013 十二月 1, 於 : Journal of Virology. 87, 23, p. 12675-12684 10 p.

研究成果: Article

Hepatitis B virus
surface antigens
Surface Antigens
binding proteins
Zinc
2012
3 引文 (Scopus)

Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition

Cheng, C. H., Chen, Y. C., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Chen, C. Y. & Chuang, W. J., 2012 十二月 1, 於 : Protein Science. 21, 12, p. 1872-1884 13 p.

研究成果: Article

Scaffolds
Integrins
Proteins
mambin
rhodostomin
9 引文 (Scopus)
integrins
Integrins
mutation
mutants
Mutation
9 引文 (Scopus)
Streptococcus
Quorum Sensing
Cysteine Proteases
Virulence Factors
Mutation
6 引文 (Scopus)

Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin

Chen, Y. C., Cheng, C. H., Shiu, J. H., Chang, Y. T., Chang, Y. S., Huang, C. H., Lee, J. C. & Chuang, W. J., 2012 十二月 5, 於 : Toxicon. 60, 8, p. 1342-1348 7 p.

研究成果: Article

Disintegrins
Pichia
Integrins
Platelets
Platelet Aggregation
9 引文 (Scopus)

Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of KV1.3 Channel Blockers

Anangi, R., Koshy, S., Huq, R., Beeton, C., Chuang, W. J. & King, G. F., 2012 十二月 29, 於 : PloS one. 7, 12, e52965.

研究成果: Article

Pichia pastoris
Pichia
T-cells
toxins
Disulfides
2011
14 引文 (Scopus)

Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan

Chiang-Ni, C., Wu, A. B., Liu, C. C., Chen, K. T., Lin, Y. S., Chuang, W. J., Fang, H. Y. & Wu, J. J., 2011 十二月 1, 於 : Journal of Microbiology, Immunology and Infection. 44, 6, p. 424-429 6 p.

研究成果: Article

Streptococcus pyogenes
Taiwan
Cellulitis
Infection
Population
7 引文 (Scopus)
Epitope Mapping
Monoclonal Antibodies
Cysteine Proteases
Allergens
Immunoglobulin E
12 引文 (Scopus)

Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway

Hsu, C. C., Chuang, W-J., Chang, C. H., Tseng, Y. L., Peng, H. C. & Huang, T. F., 2011 三月 1, 於 : Journal of Thrombosis and Haemostasis. 9, 3, p. 593-602 10 p.

研究成果: Article

Disintegrins
Integrins
Lipopolysaccharides
Phagocytes
Monocytes
18 引文 (Scopus)
Monomers
Dimers
DNA
Hinges
Forkhead Transcription Factors
7 引文 (Scopus)
Streptococcus pyogenes
Immunity
Immunoglobulin G
Antibodies
Enzymes
2010
4 引文 (Scopus)

Agaricus blazei Murill ameliorates myocardial ischemia-reperfusion injury

Huang, C. H., Tsai, H. N., Peng, R. H., Hsieh, Y. H., Chuang, W-J., Hsu, G. C., Huang, W-Y. & Chen, W. J., 2010 十二月 1, 於 : Acta Cardiologica Sinica. 26, 4, p. 235-241 7 p.

研究成果: Article

Agaricus
Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Myocardial Reperfusion
13 引文 (Scopus)

Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3

Anangi, R., Chen, C. C., Lin, Y. W., Cheng, Y. R., Cheng, C. H., Chen, Y. C., Chu, Y. P. & Chuang, W. J., 2010 十二月 1, 於 : Toxicon. 56, 8, p. 1388-1397 10 p.

研究成果: Article

Acid Sensing Ion Channel Blockers
Pichia
Acid Sensing Ion Channels
Nuclear magnetic resonance
Neurology
15 引文 (Scopus)
Molecular Mimicry
B-Lymphocytes
Endothelial Cells
Monoclonal Antibodies
Bovine Serum Albumin
20 引文 (Scopus)

Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2010 四月 1, 於 : International Journal of Medical Microbiology. 300, 4, p. 259-264 6 p.

研究成果: Article

Streptococcus pyogenes
Peroxides
Ferritins
Hydrogen Peroxide
Oxidative Stress
2009
12 引文 (Scopus)
Streptococcus pyogenes
Taiwan
Epidemiology
Scarlet Fever
Pharyngitis
8 引文 (Scopus)
Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
14 引文 (Scopus)
Streptococcus
Growth
Necrotizing Fasciitis
Multilocus Sequence Typing
Streptococcus pyogenes
17 引文 (Scopus)

Procaspase 8 and bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin B-induced apoptosis

Chang, C. W., Tsai, W. H., Chuang, W. J., Lin, Y. S., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2009 十一月 27, 於 : Journal of Biological Chemistry. 284, 48, p. 33195-33205 11 p.

研究成果: Article

Caspase 8
Small Interfering RNA
Phosphorylation
Apoptosis
Tyrosine
13 引文 (Scopus)

Solution structure and backbone dynamics of streptopain: Insight into diverse substrate specificity

Wang, C. C., Houng, H. C., Chen, C. L., Wang, P. J., Kuo, C. F., Lin, Y. S., Wu, J. J., Lin, M. T., Liu, C. C., Huang, W. & Chuang, W. J., 2009 四月 17, 於 : Journal of Biological Chemistry. 284, 16, p. 10957-10967 11 p.

研究成果: Article

streptopain
Substrate Specificity
Substrates
X-Rays
X rays
4 引文 (Scopus)

The IL-8 production by streptococcal pyrogenic exotoxin B

Chang, C. W., Wu, S. Y., Chuang, W-J., Lin, Y-S., Wu, S. Y., Liu, C-C., Tsai, P-J. & Lin, M. T., 2009 十一月 1, 於 : Experimental Biology and Medicine. 234, 11, p. 1316-1326 11 p.

研究成果: Article

Caspase 8
Interleukin-8
Chemical activation
CD95 Antigens
Phosphorylation
2008
32 引文 (Scopus)

An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses

Tsou, C. C., Chiang-Ni, C., Lin, Y. S., Chuang, W. J., Lin, M. T., Liu, C. C. & Wu, J. J., 2008 九月 1, 於 : Infection and Immunity. 76, 9, p. 4038-4045 8 p.

研究成果: Article

Iron-Binding Proteins
Streptococcus pyogenes
Hydrogen Peroxide
Iron
Peroxides
30 引文 (Scopus)
Complement C3
Complement Activation
Neutrophils
Serum
Zymosan
5 引文 (Scopus)
Streptococcal Infections
Streptococcus
Taiwan
Molecular Epidemiology
Erythromycin
4 引文 (Scopus)

Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia

Hsu, J. F., Chuang, W. J., Shiesh, S. C., Lin, Y. S., Liu, C. C., Wang, C. C., Fu, T. N., Tsai, J. H., Tsai, W. L., Huang, Y. J., Hsieh, Y. H., Wu, J. J., Lin, M. T. & Huang, W., 2008 八月 1, 於 : Journal of Infectious Diseases. 198, 3, p. 367-374 8 p.

研究成果: Article

Adenosylhomocysteinase
Cysteine Proteases
Impetigo
Myositis
Pharyngitis
14 引文 (Scopus)

Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through αvβ3 integrin and Fas

Tsai, W. H., Chang, C. W., Lin, Y. S., Chuang, W. J., Wu, J. J., Liu, C. C., Tsai, P. J. & Lin, M. T., 2008 四月 1, 於 : Infection and Immunity. 76, 4, p. 1349-1357 9 p.

研究成果: Article

Integrins
Apoptosis
Anti-Idiotypic Antibodies
A549 Cells
erythrogenic toxin
20 引文 (Scopus)
Streptococcus pyogenes
Streptococcus
Cytokines
Interleukin-18
Interleukin-12
8 引文 (Scopus)
Genetic Terminator Regions
Streptococcus pyogenes
Operon
RNA
Genes
2007
16 引文 (Scopus)
Secondary Protein Structure
Cluster analysis
Chemical shift
Oxidation-Reduction
Cluster Analysis
14 引文 (Scopus)

Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines

Kuo, C. F., Chen, C. C., Lin, C. F., Jan, M. S., Huang, R. Y., Luo, Y. H., Chuang, W. J., Sheu, C. C. & Lin, Y. S., 2007 二月 1, 於 : Food and Chemical Toxicology. 45, 2, p. 278-285 8 p.

研究成果: Article

Cordyceps
Ophiocordyceps sinensis
exotoxins
U937 Cells
Mycelium
23 引文 (Scopus)

Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells

Su, C. C., Lin, Y. P., Cheng, Y. J., Huang, J. Y., Chuang, W. J., Shan, Y. S. & Yang, B. C., 2007 十月 1, 於 : Journal of Immunology. 179, 7, p. 4589-4597 9 p.

研究成果: Article

Phosphatidylinositol 3-Kinase
Integrins
Apoptosis
T-Lymphocytes
Jurkat Cells
14 引文 (Scopus)

Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis

Luo, Y. H., Kuo, C. F., Huang, K. J., Wu, J. J., Lei, H. Y., Lin, M. T., Chuang, W. J., Liu, C. C., Lin, C. F. & Lin, Y. S., 2007 九月 1, 於 : Kidney international. 72, 6, p. 716-724 9 p.

研究成果: Article

Exotoxins
Glomerulonephritis
Antibodies
Complement Activation
Proteinuria
4 引文 (Scopus)

The fate of SPE B after internalization and its implication in SPEB-induced apoptosis.

Chang, C. W., Tsai, W. H., Chuang, W-J., Lin, Y-S., Wu, J. J., Liu, C-C., Tsai, P-J. & Lin, M. T., 2007 一月 1, 於 : Journal of biomedical science. 14, 3, p. 419-427 9 p.

研究成果: Article

Apoptosis
Fluorescein-5-isothiocyanate
Chloroquine
Lysosomes
Degradation