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以小鼠模型、病人檢體及CRISPR/dCas9干擾性基因編輯工具研究細胞凋亡有關之長鏈非編碼核糖核酸於全身性紅斑狼瘡之角色
Wang, Chrong-Reen
(PI)
內科學科
研究計畫
:
Research project
概覽
指紋
指紋
探索此專案觸及的研究主題。這些標籤是根據基礎獎勵/補助款而產生。共同形成了獨特的指紋。
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Keyphrases
Adverse Effects
8%
Apoptosis
100%
Apoptosis Analysis
8%
Apoptotic Cells
8%
Apoptotic Pathway
8%
Apoptotic Process
8%
Blood Samples
8%
C57BL
25%
Cell Apoptosis
8%
Cell Manufacturing
8%
Cell Population
8%
Chronic Autoimmune Disease
8%
Clinical Samples
8%
CRISPR Activation
100%
CRISPR Interference (CRISPRi)
8%
CRISPR-dCas9
16%
DCas9
100%
Disease Activity
8%
Doxorubicin
8%
Dysregulated
8%
Expected Outcomes
8%
First Year
8%
Genome Editing
100%
Hemoglobulin
8%
High Failure Rate
8%
Histological Analysis
8%
Human Cells
8%
IL-2 Expression
8%
Immune Complex Formation
16%
Immunoblot
8%
Immunomodulatory Drugs (IMiDs)
8%
In Situ Hybridization
8%
In Vivo Knockdown
8%
Inflammation
8%
Intravenous Administration
8%
Jurkat
8%
Jurkat Cells
8%
Kidney Tissue
8%
Kinetic Profile
8%
Knockdown
8%
LincRNA-p21
50%
LncRNA Expression
16%
Long Non-coding RNA (LncRNA)
100%
Luciferase Reporter Assay
8%
Lung Tissue
8%
Lupus Model
25%
Lupus Nephritis
33%
Methyl-CpG-binding Protein 2 (MeCP2)
8%
MicroRNA
8%
MiRNA Microarray
8%
MiRNA Target
25%
MiRNA-181a
8%
Mononuclear Cells
8%
Mouse Model
100%
Novel Targeted Therapy
8%
Nuclear Autoantigens
16%
P21 Expression
16%
Pathogenic Mechanism
8%
Pathogenic Role
8%
Patient Samples
100%
PCR Screening
8%
Peripheral Blood Mononuclear Cells
8%
Phagocytes
8%
Pro-apoptosis
8%
Proteinuria
8%
Pulmonary Hemorrhage
33%
Putative Drug Targets
8%
Quantitative PCR
25%
RAW264.7
8%
Repressor Domain
8%
Single Guide RNA (sgRNA)
8%
Spleen Tissue
8%
Stable Transfectants
8%
Systemic Lupus Erythematosus
100%
Systemic Lupus Erythematosus Patient
8%
Transfect
8%
Transfected Cells
8%
Immunology and Microbiology
Autoantigen
28%
Autoimmune Disease
14%
C57BL 6 Mouse
28%
Cell Subpopulation
14%
Clustered Regularly Interspaced Short Palindromic Repeat
42%
Complex Formation
28%
ELISA
14%
Gene Editing
100%
Human Cell
14%
Immune Complex
28%
Immunosuppressive Drug
14%
In Situ Hybridization
14%
Inflammation
14%
Interleukin 2
14%
Lung
14%
Lupus Erythematosus
100%
Mononuclear Cell
28%
Mouse Model
100%
Nephritis
57%
Phagocyte
14%
Programmed Cell Death
100%
Real Time Polymerase Chain Reaction
28%
Real-Time Polymerase Chain Reaction
14%
Repressor Gene
14%
Systemic Lupus Erythematosus
100%
Western Blot
14%
Pharmacology, Toxicology and Pharmaceutical Science
Adverse Event
9%
Autoantigen
18%
Autoimmune Disease
9%
C57BL 6 Mouse
18%
Disease Activity
9%
Doxorubicin
9%
Enzyme-Linked Immunosorbent Assay
9%
Immunosuppressive Agent
9%
Inflammation
9%
Interleukin 2
9%
Long Untranslated RNA
100%
Luciferase
9%
Lung Hemorrhage
36%
Lupus Erythematosus Nephritis
36%
microRNA
36%
Mouse Model
100%
Pathogenesis
9%
Proteinuria
9%
Systemic Lupus Erythematosus
100%
Western Blot
9%