β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity

Yuh Fung Chen, Ping Chung Kuo, Hsiu Hui Chan, I. Je Kuo, Fu Wen Lin, Chung Ren Su, Mei Lin Yang, Ding Tzai Li, Tian Shung Wu

研究成果: Article

40 引文 斯高帕斯(Scopus)

摘要

The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC50 values in the range of 11.3 to 19.3 μM.

原文English
頁(從 - 到)1993-1998
頁數6
期刊Journal of Natural Products
73
發行號12
DOIs
出版狀態Published - 2010 十二月 27

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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