β-transducin repeat-containing protein 1 (β-TrCP1)-mediated silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) protein degradation promotes tumor necrosis factor α (TNFα)-induced inflammatory gene expression

Kuo Sheng Hsu, Hung Ying Kao

研究成果: Article

4 引文 斯高帕斯(Scopus)

摘要

Background: SMRT is a transcriptional corepressor, and β-TrCP1 is a subunit of ubiquitin E3 ligase. Results: TNFα stimulation up-regulatesβ-TrCP1, which promotes SMRT polyubiquitination and proteolysis.β-TrCP1 knockdown in endothelial cells enhances SMRT occupancy on target gene promoters and decreases their expression. Conclusion: The TNFα downstream β-TrCP1-SMRT axis derepresses SMRT-targeted genes. Significance: Understanding the TNFα;-β-TrCP1-SMRT axis in the proinflammatory response will further our understanding of inflammation- associated diseases.

原文English
頁(從 - 到)25375-25386
頁數12
期刊Journal of Biological Chemistry
288
發行號35
DOIs
出版狀態Published - 2013 八月 30

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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