TY - JOUR
T1 - β-transducin repeat-containing protein 1 (β-TrCP1)-mediated silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) protein degradation promotes tumor necrosis factor α (TNFα)-induced inflammatory gene expression
AU - Hsu, Kuo Sheng
AU - Kao, Hung Ying
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: SMRT is a transcriptional corepressor, and β-TrCP1 is a subunit of ubiquitin E3 ligase. Results: TNFα stimulation up-regulatesβ-TrCP1, which promotes SMRT polyubiquitination and proteolysis.β-TrCP1 knockdown in endothelial cells enhances SMRT occupancy on target gene promoters and decreases their expression. Conclusion: The TNFα downstream β-TrCP1-SMRT axis derepresses SMRT-targeted genes. Significance: Understanding the TNFα;-β-TrCP1-SMRT axis in the proinflammatory response will further our understanding of inflammation- associated diseases.
AB - Background: SMRT is a transcriptional corepressor, and β-TrCP1 is a subunit of ubiquitin E3 ligase. Results: TNFα stimulation up-regulatesβ-TrCP1, which promotes SMRT polyubiquitination and proteolysis.β-TrCP1 knockdown in endothelial cells enhances SMRT occupancy on target gene promoters and decreases their expression. Conclusion: The TNFα downstream β-TrCP1-SMRT axis derepresses SMRT-targeted genes. Significance: Understanding the TNFα;-β-TrCP1-SMRT axis in the proinflammatory response will further our understanding of inflammation- associated diseases.
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U2 - 10.1074/jbc.M113.473124
DO - 10.1074/jbc.M113.473124
M3 - Article
C2 - 23861398
AN - SCOPUS:84883320839
SN - 0021-9258
VL - 288
SP - 25375
EP - 25386
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 35
ER -