Background: SMRT is a transcriptional corepressor, and β-TrCP1 is a subunit of ubiquitin E3 ligase. Results: TNFα stimulation up-regulatesβ-TrCP1, which promotes SMRT polyubiquitination and proteolysis.β-TrCP1 knockdown in endothelial cells enhances SMRT occupancy on target gene promoters and decreases their expression. Conclusion: The TNFα downstream β-TrCP1-SMRT axis derepresses SMRT-targeted genes. Significance: Understanding the TNFα;-β-TrCP1-SMRT axis in the proinflammatory response will further our understanding of inflammation- associated diseases.
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