摘要
Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.
原文 | English |
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頁(從 - 到) | 2521-2530 |
頁數 | 10 |
期刊 | Journal of Natural Products |
卷 | 78 |
發行號 | 11 |
DOIs | |
出版狀態 | Published - 2015 11月 25 |
All Science Journal Classification (ASJC) codes
- 分析化學
- 分子醫學
- 藥理
- 藥學科學
- 藥物發現
- 補充和替代醫學
- 有機化學