γ- and δ-Lactams from the Leaves of Clausena lansium

De Yang Shen, Thi Ngan Nguyen, Shwu Jen Wu, Young Ji Shiao, Hsin-Yi Hung, Ping-Chung Kuo, Daih Huang Kuo, Tran Dinh Thang, Tian-Shung Wu

研究成果: Article

14 引文 斯高帕斯(Scopus)

摘要

Eight new clausenamides, including three γ-lactams (1-3), four γ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.

原文English
頁(從 - 到)2521-2530
頁數10
期刊Journal of Natural Products
78
發行號11
DOIs
出版狀態Published - 2015 十一月 25

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • 引用此

    Shen, D. Y., Nguyen, T. N., Wu, S. J., Shiao, Y. J., Hung, H-Y., Kuo, P-C., Kuo, D. H., Thang, T. D., & Wu, T-S. (2015). γ- and δ-Lactams from the Leaves of Clausena lansium. Journal of Natural Products, 78(11), 2521-2530. https://doi.org/10.1021/acs.jnatprod.5b00148