τ Proteins in Serum Predict Outcome After Severe Traumatic Brain Injury

Po Chou Liliang, Cheng Loong Liang, Hui Ching Weng, Kang Lu, Kuo Wei Wang, Han Jung Chen, Jiin Haur Chuang

研究成果: Article

84 引文 斯高帕斯(Scopus)

摘要

Background: The identification of reliable outcome predictors after traumatic brain injury (TBI) is crucial. The objective of our study was to investigate the role of τ protein as a serum marker of TBI. Methods: Thirty-four patients with severe TBI (Glasgow Coma Scale [GCS] score at admission ≤ 8) were considered. The τ protein level in the blood samples obtained at the time of admission was measured. The outcome was assessed by using the Glasgow Outcome Scale (GOS) at 6 mo post-injury. Demographic, clinical, and laboratory variables were analyzed to study their effect on the outcome. Results: τ Protein levels were higher in the poor outcome group (436.2 ± 473.6 pg/mL) than in the good outcome group (51.6 ± 81.5 pg/mL) (P < 0.0001). Univariate analyses demonstrated that poor outcome was significantly associated with a poor GCS score (P = 0.001), higher serum τ protein levels (P < 0.001), abnormal pupil light reflex (P = 0.013), and basal cistern compression on computed tomogram (CT) (P = 0.026). Multivariate analyses revealed that a poor GCS score (P = 0.049) and higher serum τ protein levels (P = 0.043) were independent prognostic factors for poor outcome. The receiver-operating characteristic (ROC) curve demonstrated that a τ protein level ≥ 114.5 pg/mL yielded 88% sensitivity and 94% specificity for predicting a poor outcome. Conclusions: These results suggest that in addition to GCS; serum τ protein levels may serve as indicators for the prediction of outcome following severe TBI. However; it should be viewed with caution because of the small sample size and wide standard deviations.

原文English
頁(從 - 到)302-307
頁數6
期刊Journal of Surgical Research
160
發行號2
DOIs
出版狀態Published - 2010 五月 15

All Science Journal Classification (ASJC) codes

  • Surgery

指紋 深入研究「τ Proteins in Serum Predict Outcome After Severe Traumatic Brain Injury」主題。共同形成了獨特的指紋。

  • 引用此

    Liliang, P. C., Liang, C. L., Weng, H. C., Lu, K., Wang, K. W., Chen, H. J., & Chuang, J. H. (2010). τ Proteins in Serum Predict Outcome After Severe Traumatic Brain Injury. Journal of Surgical Research, 160(2), 302-307. https://doi.org/10.1016/j.jss.2008.12.022