13-Methyl-3,4-seco-ent-podocarpanes, rare C18-diterpenoids from the roots of Flueggea virosa

Chih Hua Chao, Ju Chien Cheng, De Yang Shen, Hui Chi Huang, Yang Chang Wu, Tian Shung Wu

研究成果: Article

3 引文 斯高帕斯(Scopus)

摘要

As a part of our continuing search for anti-HCV agents from a medicinal plant, Flueggea virosa, we identified fourteen new ingredients, including 13-methyl-3,4-seco-ent-podocarpanes (1-13) and a new naphthalene derivative (14). Their structures were determined by analysis of 2D NMR spectroscopic data, while their absolute configurations were determined by comparison of specific optical rotations with related analogues in the literature. The therapeutic potential against hepatitis C virus (HCV) infection was evaluated for the isolates. Compound 8 showed the most potent anti-HCV activity with a therapeutic index (TI = IC50/EC50) of 100.5.

原文English
頁(從 - 到)34708-34714
頁數7
期刊RSC Advances
6
發行號41
DOIs
出版狀態Published - 2016 一月 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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    Chao, C. H., Cheng, J. C., Shen, D. Y., Huang, H. C., Wu, Y. C., & Wu, T. S. (2016). 13-Methyl-3,4-seco-ent-podocarpanes, rare C18-diterpenoids from the roots of Flueggea virosa. RSC Advances, 6(41), 34708-34714. https://doi.org/10.1039/c6ra00843g