2-Adamantanamine produces prolonged spinal block in rats

Yu Wen Chen, Chia Ming Chen, Kuo Sheng Liu, Jhi Joung Wang, Ching Hsia Hung

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

We aimed to investigate the local anesthetic effect of 2-adamantanamine in spinal anesthesia. The dose–response curves were constructed after intrathecally injecting the rats with five doses of 2-adamantanamine and a common local anesthetic mepivacaine. The quality and duration of 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block were compared with that of mepivacaine. We revealed that 2-adamantanamine provoked spinal nociceptive, proprioceptive and motor block dose-dependently. On the 50% effective dose (ED50) basis, the rank of potency was mepivacaine > 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block (p < 0.05 for the differences). 2-Adamantanamine, but not mepivacaine produced more nociceptive block than motor block (p < 0.05). At the equianesthetic doses (ED75, ED50, and ED25), the nociceptive block duration caused by 2-adamantanamine was greater than that caused by mepivacaine (p < 0.01 for the differences). These preclinical data showed that 2-adamantanamine is less potent than mepivacaine, while 2-adamantanamine provokes greater duration of spinal nociceptive block than mepivacaine. Furthermore, 2-adamantanamine demonstrates a more nociceptive-selective action over motor block.

原文English
頁(從 - 到)168-172
頁數5
期刊Neuroscience Letters
653
DOIs
出版狀態Published - 2017 七月 13

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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