22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control

Shuenn-Yuh Lee, Chieh Tsou, Peng Wei Huang, Po Hao Cheng, Chi Chung Liao, Zhan Xien Liao, Hao Yun Lee, Chou-Ching Lin, Chia Hsiang Hsieh

研究成果: Conference contribution

摘要

The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.

原文English
主出版物標題2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
發行者Institute of Electrical and Electronics Engineers Inc.
頁面372-374
頁數3
ISBN(電子)9781538685310
DOIs
出版狀態Published - 2019 三月 6
事件2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States
持續時間: 2019 二月 172019 二月 21

出版系列

名字Digest of Technical Papers - IEEE International Solid-State Circuits Conference
2019-February
ISSN(列印)0193-6530

Conference

Conference2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
國家United States
城市San Francisco
期間19-02-1719-02-21

指紋

Electroencephalography
Monitoring
Graphical user interfaces
Animals
Tissue
Experiments
System-on-chip

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

引用此文

Lee, S-Y., Tsou, C., Huang, P. W., Cheng, P. H., Liao, C. C., Liao, Z. X., ... Hsieh, C. H. (2019). 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. 於 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 (頁 372-374). [8662385] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; 卷 2019-February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2019.8662385
Lee, Shuenn-Yuh ; Tsou, Chieh ; Huang, Peng Wei ; Cheng, Po Hao ; Liao, Chi Chung ; Liao, Zhan Xien ; Lee, Hao Yun ; Lin, Chou-Ching ; Hsieh, Chia Hsiang. / 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. 頁 372-374 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).
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abstract = "The number of studies on closed-loop detection and electrical stimulation systems [1]-[2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce enough stimulation to affect a large range of nerves. However, all nerves near the stimulus are excited and hurt, and over time, currents start to exceed acceptable limits. Therefore, optogenetic stimulation [3]-[4] has become compelling in recent years due to several advantages: (1) no artificial noise on the EEG; (2) ability to stimulate specific nerves; and (3) no injurious effects on nerves. In this study, a wireless programmable stimulating system-on-chip (WPSSoC) is reported that provides wireless open/closed-loop optogenetic and electrical stimulation to improve treatment for epilepsy suppression. The system is demonstrated on programmable stimulation parameters wirelessly controlled by a software Graphical User Interface (GUI) on a computer. Moreover, an animal experiment conducted on optogenetic tissue was successful, thereby demonstrating that the nerve injury on optogenetic stimulation is lower than that of electrical stimulation.",
author = "Shuenn-Yuh Lee and Chieh Tsou and Huang, {Peng Wei} and Cheng, {Po Hao} and Liao, {Chi Chung} and Liao, {Zhan Xien} and Lee, {Hao Yun} and Chou-Ching Lin and Hsieh, {Chia Hsiang}",
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Lee, S-Y, Tsou, C, Huang, PW, Cheng, PH, Liao, CC, Liao, ZX, Lee, HY, Lin, C-C & Hsieh, CH 2019, 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. 於 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019., 8662385, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, 卷 2019-February, Institute of Electrical and Electronics Engineers Inc., 頁 372-374, 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019, San Francisco, United States, 19-02-17. https://doi.org/10.1109/ISSCC.2019.8662385

22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. / Lee, Shuenn-Yuh; Tsou, Chieh; Huang, Peng Wei; Cheng, Po Hao; Liao, Chi Chung; Liao, Zhan Xien; Lee, Hao Yun; Lin, Chou-Ching; Hsieh, Chia Hsiang.

2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 372-374 8662385 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; 卷 2019-February).

研究成果: Conference contribution

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AU - Lee, Hao Yun

AU - Lin, Chou-Ching

AU - Hsieh, Chia Hsiang

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Lee S-Y, Tsou C, Huang PW, Cheng PH, Liao CC, Liao ZX 等. 22.7 A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control. 於 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 372-374. 8662385. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). https://doi.org/10.1109/ISSCC.2019.8662385