3-D magnetic tweezers for investigation of mechanical properties of single DNA molecules

Chi Han Chiou, Yu Yen Huang, Meng Han Chiang, Huei Huang Lee, Gwo Bin Lee

研究成果: Conference contribution

1 引文 斯高帕斯(Scopus)

摘要

This study reports a new three-dimensional (3-D) micromachined magnetic tweezers, fabricated using MEMS (micro-electro-mechanical systems) technology, for manipulating a single 2-nm diameter DNA molecule. The new apparatus uses magnetic forces to exert over 20-pN,with less heating compared to other methods, allowing the extension of the DNA molecule over its whole contour length to investigate its entropic and elastic regions. The important elastic modulus of DNA has been explored to be 453 pN at a low ionic strength. The force-extension curve for DNA molecules is found to be consistent with theoretical models. In addition to a single DNA stretching, this study also successfully demonstrated the stretching of two parallel DNA molecules, which was never reported previously in the literature.

原文English
主出版物標題19th IEEE International Conference on Micro Electro Mechanical Systems
頁面142-145
頁數4
出版狀態Published - 2006
事件19th IEEE International Conference on Micro Electro Mechanical Systems - Istanbul, Turkey
持續時間: 2006 一月 222006 一月 26

出版系列

名字Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
2006
ISSN(列印)1084-6999

Other

Other19th IEEE International Conference on Micro Electro Mechanical Systems
國家/地區Turkey
城市Istanbul
期間06-01-2206-01-26

All Science Journal Classification (ASJC) codes

  • 電子、光磁材料
  • 凝聚態物理學
  • 機械工業
  • 電氣與電子工程

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