4- And 5-aroylindoles as novel classes of potent antitubulin agents

Jing Ping Liou, Chang Ying Wu, Hsing Pang Hsieh, Chi Yen Chang, Chi Ming Chen, Ching Chuan Kuo, Jang Yang Chang

研究成果: Article同行評審

61 引文 斯高帕斯(Scopus)

摘要

A novel series of 4- and 5-aroylindole derivatives was prepared and evaluated for antitumor activity. Several compounds showed excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 13,14,15, and 18, with IC50 values of 1.9, 1.1, 1.2, and 1.8 μM, respectively, exhibited more potent inhibition of tubulin polymerization than colchicine. They also displayed antiproliferative activity, with IC50 values ranging from 10 to 43 nM in a variety of human cell lines from different organs.

原文English
頁(從 - 到)4548-4552
頁數5
期刊Journal of Medicinal Chemistry
50
發行號18
DOIs
出版狀態Published - 2007 9月 6

All Science Journal Classification (ASJC) codes

  • 分子醫學
  • 藥物發現

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