7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Jang Yang Chang, Hsing Pang Hsieh, Chi Yen Chang, Kuo Shun Hsu, Yi Fang Chiang, Chi Ming Chen, Ching Chuan Kuo, Jing Ping Liou

研究成果: Article

61 引文 斯高帕斯(Scopus)

摘要

A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

原文English
頁(從 - 到)6656-6659
頁數4
期刊Journal of Medicinal Chemistry
49
發行號23
DOIs
出版狀態Published - 2006 十一月 16

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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    Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C., & Liou, J. P. (2006). 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. Journal of Medicinal Chemistry, 49(23), 6656-6659. https://doi.org/10.1021/jm061076u