A 2.9-Kilobase noncoding nuclear RNA functions in the establishment of persistent Hz-1 viral infection

Yu Chan Chao, Song Tay Lee, Ming Chuan Chang, Hong Hwa Chen, Shih Shun Chen, Tzong Yuan Wu, Fu Hwa Liu, Err Lieh Hsu, Roger F. Hou

研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)

摘要

Differential viral gene expression during both productive and persistent infections of Hz-1 virus in insect cells was elucidated. Despite more than 100 viral transcripts being expressed during productive vital infection, massive vital gene shutoff was observed during viral persistency, leaving the 2.9-kb persistence-associated transcript 1 (PAT1) as the only detectable viral RNA. Persistence-associated gene 1 (pag1), which encodes PAT1, was cloned and found to contain no significant open reading frames. PAT1 is not associated with the cellular translation machinery and is located exclusively in the nucleus. Further experiments showed that PAT1 is functional in the establishment of persistent Hz-1 viral infection in the cells. All the evidence collectively indicates that PAT1 is a novel nuclear transcript of vital origin. Our results showed that although PAT1 and XIST RNA, a mammalian X-inactive specific transcript, are transcribed by different genes, they have interesting similarities.

原文English
頁(從 - 到)2233-2245
頁數13
期刊Journal of Virology
72
發行號3
DOIs
出版狀態Published - 1998 三月

All Science Journal Classification (ASJC) codes

  • 微生物學
  • 免疫學
  • 昆蟲科學
  • 病毒學

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