A bacterial binary toxin system that kills both insects and aquatic crustaceans: Photorhabdus insect-related toxins A and B

Hao Ching Wang, Shin Jen Lin, Han-Ching Wang, Ramya Kumar, Phuoc Thien Le, Jiann Horng Leu

研究成果: Review article同行評審

2 引文 斯高帕斯(Scopus)

摘要

AU Photorhabdus: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly insect-related toxins A and B (PirA and PirB):were first recognized as insecticidal toxins from Photorhabdus luminescens. However, subsequent studies showed that their homologs from Vibrio parahaemolyticus also play critical roles in the pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimps. Based on the structural features of the PirA/PirB toxins, it was suggested that they might function in the same way as a Bacillus thuringiensis Cry pore-forming toxin. However, unlike Cry toxins, studies on the PirA/PirB toxins are still scarce, and their cytotoxic mechanism remains to be clarified. In this review, based on our studies of V. parahaemolyticus PirAvp/PirBvp, we summarize the current understanding of the gene locations, expression control, activation, and cytotoxic mechanism of this type of toxin. Given the important role these toxins play in aquatic disease and their potential use in pest control applications, we also suggest further topics for research. We hope the information presented here will be helpful for future PirA/PirB studies.

原文English
文章編號e1011330
期刊PLoS pathogens
19
發行號5
DOIs
出版狀態Published - 2023 5月

All Science Journal Classification (ASJC) codes

  • 寄生物學
  • 微生物學
  • 免疫學
  • 分子生物學
  • 遺傳學
  • 病毒學

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