A canine non-weight-bearing model with radial neurectomy for rotator cuff repair

Xiaoxi Ji, Nirong Bao, Kai Nan An, Peter C. Amadio, Scott P. Steinmann, Chunfeng Zhao

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Background: The major concern of using a large animal model to study rotator cuff repair is the high rate of repair retears. The purpose of this study was to test a non-weight-bearing (NWB) canine model for rotator cuff repair research. Methods: First, in the in vitro study, 18 shoulders were randomized to 3 groups. 1) Full-width transections repaired with modified Mason-Allen sutures using 3-0 polyglactin suture, 2) Group 1 repaired using number 2 (#2) polyester braid and long-chain polyethylene suture, and 3) Partial-width transections leaving the superior 2 mm infraspinatus tendon intact without repair. In the in vivo study of 6 dogs, the infraspinatus tendon was partially transected as the same as the in vitro group 3. A radial neurectomy was performed to prevent weight bearing. The operated limb was slung in a custom-made jacket for 6 weeks. Results: In the in vitro study, mean ultimate tensile load and stiffness in Group 2 were significantly higher than Group 1 and 3 (p<0.05). In the in vivo study, gross inspection and histologyshowed that the preserved superior 2-mm portion of the infraspinatus tendon remained intact with normal structure. Conclusions: Based on the biomechanical and histological findings, this canine NWB model may be an appropriate and useful model for studies of rotator cuff repair.

原文English
文章編號e0130576
期刊PloS one
10
發行號6
DOIs
出版狀態Published - 2015 六月 24

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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