A cellular ELISA to screen lectin-like compounds for cancer cell binding

C. P. Chang; W. C. Cheng; H. Y. Lei

doi:10.2174/1570180053765228

A cellular ELISA to screen lectin-like compounds for cancer cell binding

C. P. Chang, W. C. Cheng, H. Y. Lei

微生物學科暨微生物及免疫學研究所

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

摘要

Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

原文	English
頁（從 - 到）	182-188
頁數	7
期刊	Letters in Drug Design and Discovery
卷	2
發行號	3
DOIs	https://doi.org/10.2174/1570180053765228
出版狀態	Published - 2005 5月

All Science Journal Classification (ASJC) codes

分子醫學
藥學科學
藥物發現

UN SDG

此研究成果有助於以下永續發展目標

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10.2174/1570180053765228

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abstract = "Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.",

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AB - Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

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A cellular ELISA to screen lectin-like compounds for cancer cell binding

摘要

All Science Journal Classification (ASJC) codes

UN SDG

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