A Clinical Study of 130 Patients with Biliary Tract Cancers and Periampullary Tumors

Wu Chou Su, Kuo Kuan Chan, Xi Zhang Lin, Pin Wen Lin, Nan Haw Chow, Jeng Shiann Shin, Chiung Yu Chen, Chao Jung Tsao

研究成果: Article

23 引文 (Scopus)

摘要

A retrospective review of 130 patients with peripheral-type cholangiocarcinomas (PTCC), hilar-type cholangiocarcinomas (HTCC), extrahepatic cholan-giocarcinomas (EHCC), gallbladder cancers (GBCA), and periampullary cancers (PACA), seen at National Cheng Kung University Hospital and Tainan Municipal Hospital from June 1987 to July 1993 was performed. There were 47 (36%) HTCC, 32 (25%) PACA, 24 (19%) PTCC, 17 (13%) GBCA, and 10 (8%) EHCC patients. The distribution is completely different from that reported in western countries. These cancers mainly occur in elderly patients. HTCC and GBCA were predominantly noted in female patients. Biliary cancers in Taiwan were not related to liver fluke infestation, inflammatory bowel disease or hepatitis B virus infection. However, a close association with biliary lithiasis was found. The incidence of gallstones was 67, 39,20,29 and 19% for PTCC, HTCC, EHCC, GBCA and PACA, respectively. The most common presentation for PTCC and GBCA was abdominal pain, or jaundice for HTCC, EHCC and PACA. These symptoms correlate well with the location of the tumors. Among serum tumor markers, the elevation of CA19-9 was most frequent, occurring in 86% of the patients while CA125 and CEA occurred in 47% and 30% of the patients, respectively. During the course of disease, infection developed in 61 % of the patients and was the main cause of death in 25%. Biliary tract infection and sepsis were the two leading manifestations and occurred in 49% and 32% of the patients, respectively. Overall survival was poor except in patients whose tumor could be completely resected.

原文English
頁(從 - 到)488-493
頁數6
期刊Oncology (Switzerland)
53
發行號6
DOIs
出版狀態Published - 1996 一月 1

指紋

Biliary Tract Neoplasms
Klatskin Tumor
Gallbladder Neoplasms
Cholangiocarcinoma
Neoplasms
Municipal Hospitals
Clinical Studies
Fasciola hepatica
Lithiasis
Biliary Tract
Gallstones
Virus Diseases
Tumor Biomarkers
Jaundice
Infection
Taiwan
Inflammatory Bowel Diseases
Hepatitis B virus
Abdominal Pain
Cause of Death

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

Su, Wu Chou ; Chan, Kuo Kuan ; Lin, Xi Zhang ; Lin, Pin Wen ; Chow, Nan Haw ; Shin, Jeng Shiann ; Chen, Chiung Yu ; Tsao, Chao Jung. / A Clinical Study of 130 Patients with Biliary Tract Cancers and Periampullary Tumors. 於: Oncology (Switzerland). 1996 ; 卷 53, 編號 6. 頁 488-493.
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title = "A Clinical Study of 130 Patients with Biliary Tract Cancers and Periampullary Tumors",
abstract = "A retrospective review of 130 patients with peripheral-type cholangiocarcinomas (PTCC), hilar-type cholangiocarcinomas (HTCC), extrahepatic cholan-giocarcinomas (EHCC), gallbladder cancers (GBCA), and periampullary cancers (PACA), seen at National Cheng Kung University Hospital and Tainan Municipal Hospital from June 1987 to July 1993 was performed. There were 47 (36{\%}) HTCC, 32 (25{\%}) PACA, 24 (19{\%}) PTCC, 17 (13{\%}) GBCA, and 10 (8{\%}) EHCC patients. The distribution is completely different from that reported in western countries. These cancers mainly occur in elderly patients. HTCC and GBCA were predominantly noted in female patients. Biliary cancers in Taiwan were not related to liver fluke infestation, inflammatory bowel disease or hepatitis B virus infection. However, a close association with biliary lithiasis was found. The incidence of gallstones was 67, 39,20,29 and 19{\%} for PTCC, HTCC, EHCC, GBCA and PACA, respectively. The most common presentation for PTCC and GBCA was abdominal pain, or jaundice for HTCC, EHCC and PACA. These symptoms correlate well with the location of the tumors. Among serum tumor markers, the elevation of CA19-9 was most frequent, occurring in 86{\%} of the patients while CA125 and CEA occurred in 47{\%} and 30{\%} of the patients, respectively. During the course of disease, infection developed in 61 {\%} of the patients and was the main cause of death in 25{\%}. Biliary tract infection and sepsis were the two leading manifestations and occurred in 49{\%} and 32{\%} of the patients, respectively. Overall survival was poor except in patients whose tumor could be completely resected.",
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A Clinical Study of 130 Patients with Biliary Tract Cancers and Periampullary Tumors. / Su, Wu Chou; Chan, Kuo Kuan; Lin, Xi Zhang; Lin, Pin Wen; Chow, Nan Haw; Shin, Jeng Shiann; Chen, Chiung Yu; Tsao, Chao Jung.

於: Oncology (Switzerland), 卷 53, 編號 6, 01.01.1996, p. 488-493.

研究成果: Article

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AU - Chow, Nan Haw

AU - Shin, Jeng Shiann

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AU - Tsao, Chao Jung

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AB - A retrospective review of 130 patients with peripheral-type cholangiocarcinomas (PTCC), hilar-type cholangiocarcinomas (HTCC), extrahepatic cholan-giocarcinomas (EHCC), gallbladder cancers (GBCA), and periampullary cancers (PACA), seen at National Cheng Kung University Hospital and Tainan Municipal Hospital from June 1987 to July 1993 was performed. There were 47 (36%) HTCC, 32 (25%) PACA, 24 (19%) PTCC, 17 (13%) GBCA, and 10 (8%) EHCC patients. The distribution is completely different from that reported in western countries. These cancers mainly occur in elderly patients. HTCC and GBCA were predominantly noted in female patients. Biliary cancers in Taiwan were not related to liver fluke infestation, inflammatory bowel disease or hepatitis B virus infection. However, a close association with biliary lithiasis was found. The incidence of gallstones was 67, 39,20,29 and 19% for PTCC, HTCC, EHCC, GBCA and PACA, respectively. The most common presentation for PTCC and GBCA was abdominal pain, or jaundice for HTCC, EHCC and PACA. These symptoms correlate well with the location of the tumors. Among serum tumor markers, the elevation of CA19-9 was most frequent, occurring in 86% of the patients while CA125 and CEA occurred in 47% and 30% of the patients, respectively. During the course of disease, infection developed in 61 % of the patients and was the main cause of death in 25%. Biliary tract infection and sepsis were the two leading manifestations and occurred in 49% and 32% of the patients, respectively. Overall survival was poor except in patients whose tumor could be completely resected.

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