A computer-aided diagnosis for locating abnormalities in bone scintigraphy by a fuzzy system with a three-step minimization approach

Tang Kai Yin, Nan Tsing Chiu

研究成果: Article同行評審

57 引文 斯高帕斯(Scopus)

摘要

Bone scintigraphy is an effective method to diagnose bone diseases such as bone tumors. In the scintigraphic images, bone abnormalities are widely scattered on the whole body. Conventionally, radiologists visually check the whole-body images and find the distributed abnormalities based on their expertise. This manual process is time-consuming and it is not unusual to miss some abnormalities. In this paper, a computer-aided diagnosis (CAD) system is proposed to assist radiologists in the diagnosis of bone scintigraphy. The system will provide warning marks and abnormal scores on some locations of the images to direct radiologists' attention toward these locations. A fuzzy system called characteristic-point-based fuzzy inference system (CPFIS) is employed to implement the diagnosis system and three minimizations are used to systematically train the CPFIS. Asymmetry and brightness are chosen as the two inputs to the CPFIS according to radiologists' knowledge. The resulting CAD system is of a small-sized rule base such that the resulting fuzzy rules can be not only easily understood by radiologists, but also matched to and compared with their expert knowledge. The prototype CAD system was tested on 82 abnormal images and 27 normal images. We employed free-response receiver operating characteristics method with the mean number of false positives (FPs) and the sensitivity as performance indexes to evaluate the proposed system. The sensitivity is 91.5% (227 of 248) and the mean number of FPs is 37.3 per image. The high sensitivity and moderate numbers of FP marks per image shows that the proposed method can provide an effective second-reader information to radiologists in the diagnosis of bone scintigraphy.

原文English
頁(從 - 到)639-654
頁數16
期刊IEEE Transactions on Medical Imaging
23
發行號5
DOIs
出版狀態Published - 2004 5月

All Science Journal Classification (ASJC) codes

  • 軟體
  • 放射與超音波技術
  • 電腦科學應用
  • 電氣與電子工程

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