A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang, M. Vijaya Bhaskar Reddy, Ping Chung Kuo, Chieh Hung Huang, Hung Cheng Shih, E. Jian Lee, Mei Lin Yang, Yann Lii Leu, Tian Shung Wu

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

原文English
頁(從 - 到)371-378
頁數8
期刊European Journal of Medicinal Chemistry
48
DOIs
出版狀態Published - 2012 二月

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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