@article{bd1aeacf8e814a2d83fb40bc1663b897,
title = "A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions",
abstract = "In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.",
author = "Huang, {Guan Jhong} and {Bhaskar Reddy}, {M. Vijaya} and Kuo, {Ping Chung} and Huang, {Chieh Hung} and Shih, {Hung Cheng} and Lee, {E. Jian} and Yang, {Mei Lin} and Leu, {Yann Lii} and Wu, {Tian Shung}",
note = "Funding Information: This work was supported by a grant of National Science Council , Taiwan, Republic of China, awarded to T. S. Wu. This study is supported in part by National Cheng Kung University ( HUA100-3-2-232 ). ",
year = "2012",
month = feb,
doi = "10.1016/j.ejmech.2011.12.008",
language = "English",
volume = "48",
pages = "371--378",
journal = "CHIM.THER.",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
}