A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis

Dean Chou, John C. Vardakis, Liwei Guo, Brett J. Tully, Yiannis Ventikos

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)


This study proposes the implementation of a fully dynamic four-network poroelastic model which is underpinned by multiple-network poroelastic theory (MPET), in order to account for the effects of varying stages of aqueductal stenosis and atresia during acute hydrocephalus. The innovation of the fully dynamic MPET implementation is that it avoids the commonplace assumption of quasi-steady behaviour; instead, it incorporates all transient terms in the casting of the equations and in the numerical solution of the resulting discrete system. It was observed that the application of mild stenosis allows for a constant value of amalgamated ventricular displacement in under 2.4 h, whereas the application of a severe stenosis delays this settlement to approximately 10 h. A completely blocked aqueduct does not show a clear sign of reaching a steady ventricular displacement after 24 h. The increasing ventricular pressure (complemented with ventriculomegaly) during severe stenosis is causing the trans-parenchymal tissue region to respond, and this coping mechanism is most attenuated at the regions closest to the skull and the ventricles. After 9 h, the parenchymal tissue shows to be coping well with the additional pressure burden, since both ventriculomegaly and ventricular CSF (cerebrospinal fluid) pressure show small increases between 9 and 24 h. Localised swelling in the periventricular region could also be observed through CSF fluid content, whilst dilation results showed stretch and compression of cortical tissue adjacent to the ventricles and skull.

頁(從 - 到)2306-2312
期刊Journal of Biomechanics
出版狀態Published - 2016 7月 26

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 骨科和運動醫學
  • 生物醫學工程
  • 復健


深入研究「A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis」主題。共同形成了獨特的指紋。