A genome-wide association study identifies new loci for ACE activity: Potential implications for response to ACE inhibitor

C. M. Chung, R. Y. Wang, J. W. Chen, C. S.J. Fann, H. B. Leu, H. Y. Ho, C. T. Ting, T. H. Lin, S. H. Sheu, W. C. Tsai, J. H. Chen, Y. S. Jong, S. J. Lin, Y. T. Chen, W. H. Pan

研究成果: Article同行評審

75 引文 斯高帕斯(Scopus)

摘要

Because angiotensin-converting enzyme (ACE) activity is implicated widely in biological systems, we aimed to identify its novel quantitative trait loci for the purposes of understanding ACE activity regulation and pharmacogenetics relating to ACE inhibitor (ACEI). We performed a two-stage genome-wide association study: (1) from 400 young-onset hypertension (YOH) subjects and (2) a confirmation study with an additional 623 YOH subjects. In the first stage, eight single nucleotide polymorphisms (SNPs) of the ACE structural gene and one SNP of ABO genes were significantly associated with ACE activity. SNP rs4343 in exon17 near the well-known insertion/deletion polymorphism had the strongest association. We confirmed in the second stage that three SNPs: rs4343 in ACE gene (P=3.0 × 10-25), rs495828 (P=3.5 × 10-8) and rs8176746 (P=9.3 × 10-5) in ABO gene were significantly associated with ACE activity. We further replicated the association between ABO genotype/blood types and ACE activity in an independent YOH family study (428 hypertension pedigrees), and showed a potential differential blood pressure response to ACEI in subjects with varied numbers of ACE-activity-raising alleles. These findings may broaden our understanding of the mechanisms controlling ACE activity and advance our pharmacogenetic knowledge on ACEI.

原文English
頁(從 - 到)537-544
頁數8
期刊Pharmacogenomics Journal
10
發行號6
DOIs
出版狀態Published - 2010 十二月

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Pharmacology

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