A global metagenomic map of urban microbiomes and antimicrobial resistance

The International MetaSUB Consortium

研究成果: Article同行評審

129 引文 斯高帕斯(Scopus)

摘要

We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.

原文English
頁(從 - 到)3376-3393.e17
期刊Cell
184
發行號13
DOIs
出版狀態Published - 2021 6月 24

All Science Journal Classification (ASJC) codes

  • 一般生物化學,遺傳學和分子生物學

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