A Global Perspective on PDA Management in the Extremely Premature: Shifting Trend Toward Transcatheter Closure

Shyam Sathanandam, Patrick McNamara, Carlos Pedra, Katsuaki Toyoshima, Sophie Malekzadeh-Milani, Juliana Patkai, Osman Baspinar, Hasan Sinan Uslu, Worakan Promphan, Meera Khorana, Jieh Neng Wang, Yung Chieh Lin, Takanari Fujii, Gur Mainzer, David Salazar-Lizárraga, Horacio Márquez-Gonzalez, Himanshu Popat, Jonathan Mervis, Neoh Siew Hong, Mazeni AlwiRatthapon Wonwandee, Dietmar Schranz, Georgiev Stanimir, Ranjit Philip, Frank Ing

研究成果: Review article同行評審

2 引文 斯高帕斯(Scopus)


Patent ductus arteriosus (PDA) is a frequently encountered defect in infants born extremely premature (≤26 weeks’ gestation). Historically, closure of the PDA was performed using cyclooxygenase inhibitor medications or by surgical ligations. However, the benefits of PDA closure using these therapies have never been demonstrated, albeit studies have previously not focused on the extremely premature infants. Therefore, there was a worldwide trend toward conservative management of the PDA. With improved survival of extremely premature infants, comorbidities associated with the PDA has increased, resulting in finding alternate treatments such as transcatheter patent ductus arteriosus closure (TCPC) for this population. Currently, there is a renewed interest toward selective treatment of the PDA in this high-risk cohort of small infants. This Comprehensive Review article inspects the globally changing trends in the management of the PDA in premature infants, with a special focus on the rising adoption of TCPC. Moreover, this article compiles data from several neonatal networks worldwide to help understand the problem at hand. Understanding the current management of premature infants and their outcomes is fundamentally essential if pediatric cardiologists are to offer TCPC as a viable therapeutic option for this population. This article aims to serve as a guide for pediatric cardiologists on this topic by compiling the results on landmark clinical trials on PDA management and the controversies that arise from these trials. Comparative outcomes from several countries are presented, including interpretations and opinions of the data from experts globally. This is a step toward coming to a global consensus in PDA management in premature infants.

期刊Journal of the Society for Cardiovascular Angiography and Interventions
出版狀態Published - 2023 7月 1

All Science Journal Classification (ASJC) codes

  • 心臟病學與心血管醫學


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