A machine learning method to explore the glymphatic system via poroelastodynamics

Dean Chou, Po Yen Chen

研究成果: Article同行評審

摘要

Until recently, scientists thought that waste was cleared from the central nervous system primarily by diffusion, with waste slowly moving from the brain tissue toward the blood vessels. However, scientists have discovered a dedicated macroscopic waste clearance system, called glymphatic system, that performs efficient waste elimination through a unique system of perivascular channels formed by astrocytes, a type of glia. To better understand the complex dynamics of fluid movements in the glymphatic system, we implemented a four-compartmental poroelasticity model of the cerebral environment and used the model in a systematic and efficient parametric study aided by machine learning, a physiologically inspired perceptron method, to explore the functional impact of water transfer coefficients. The results suggested that the model captured the transport phenomenon of human brain. Moreover, within a specific distribution range of water transfer coefficients, the model indirectly predicts the existence of the glymphatic system, providing theoretical support to the glymphatic theory. Our study also demonstrates the feasibility of discovering physiological properties of complex biological systems through computer-aided modeling. Meanwhile, the presented novel method shown its potential for parametric study.

原文English
文章編號114334
期刊Chaos, solitons and fractals
178
DOIs
出版狀態Published - 2024 1月

All Science Journal Classification (ASJC) codes

  • 統計與非線性物理學
  • 數學物理學
  • 一般物理與天文學
  • 應用數學

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