A mathematical approach to effects of CTLs on cancer virotherapy in the second injection of virus

A. Ashyani, O. RabieiMotlagh, H. M. Mohammadinejad

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

This paper proposes a planar delay differential equation for cancer virotherapy. The model simulates the situation in which an oncolytic virus is injected for the second time, and the immune system suppresses the viral infection with a time delay. Our purpose is to provide theoretical conditions so that the therapy can be continued successfully. With the help of the characteristic equation, we examine the singularities and their local stability. Hopf bifurcation is also investigated around the endemic singularity. It is shown that there is a sequence of Hopf bifurcations, but the Hopf cycles do not persist continuously between the two sequential bifurcations. Finally, we see that virotherapy can be conducted successfully by controlling the delay parameter.

原文English
頁(從 - 到)78-87
頁數10
期刊Journal of Theoretical Biology
453
DOIs
出版狀態Published - 2018 九月 14

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

指紋 深入研究「A mathematical approach to effects of CTLs on cancer virotherapy in the second injection of virus」主題。共同形成了獨特的指紋。

引用此