A microfluidic and potentiostatic sensor integrated with neopterin-imprinted poly(ethylene-co-vinyl alcohol) based electrode

Chen Hsin Hsieh, Hung Yin Lin, Chien Fu Lin, Hann Huei Tsai, Ying Zong Juang, Chun Yuen Huang, Bin-Da Liu, Mei Hwa Lee

研究成果: Conference contribution

1 引文 斯高帕斯(Scopus)

摘要

Neopterin is a catabolic product of guanosine triphosphate (GTP), a purine nucleotide. In human biological fluids such as urine, neopterin concentrations indicate the activation of cellular immune activation under the control of T helper cells. High neopterin concentrations in body fluids such as serum or urine also indicate the activation of cellular immunity, which is associated with the reaction to oxidative stress. In this work, neopterin is used as the target molecule and is then imprinted onto poly(ethylene-co-vinyl alcohol) via solvent evaporation. After removing the thin-film template molecules, the membrane is used as a sensing element for electrochemical urinalysis. Miniaturized devices were fabricated for continuous measurement of biomolecules in urine. A microfluidic channel made from polydimethylsiloxane (PDMS) is mounted on the electrochemical electrode chip. To maximize electrochemical response, the sensing area is a 30 × 1 mm2. In the random urine analysis, the cyclic voltammetry measurements of neopterin with additional recovery method achieved higher than 90% recovery gave the neopterin concentration 0.5 ng/mL.

原文English
主出版物標題NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
頁面575-578
頁數4
DOIs
出版狀態Published - 2011 十月 4
事件6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 - Kaohsiung, Taiwan
持續時間: 2011 二月 202011 二月 23

出版系列

名字NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Other

Other6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
國家Taiwan
城市Kaohsiung
期間11-02-2011-02-23

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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