A microfluidic platform for diagnosis of ovarian clear cell carcinoma via quantification of fxyd2 gene

Ting Hang Liu, Chang Ni Lin, Keng Fu Hsu, Gwo Bin Lee

研究成果: Conference contribution

摘要

Ovarian cancer (OvCa), with an extremely low 5-year survival rate, is difficult for early diagnosis and prognosis monitoring due to poorly sensitive and specific cancer biomarkers for detection. In this work, an integrated microfluidic system capable of isolation of OvCa cells from liquid biopsy (such as ascites) via aptamer coated-magnetic beads and RT-qPCR for quantification of the FXYD2 expression level was developed for automatic diagnosis of ovarian clear cell carcinoma. Experimental results showed that a limit of detection could be as low as 10 cells/reaction, which is satisfactory for future clinical trials.

原文English
主出版物標題23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
發行者Chemical and Biological Microsystems Society
頁面622-623
頁數2
ISBN(電子)9781733419000
出版狀態Published - 2019
事件23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
持續時間: 2019 十月 272019 十月 31

出版系列

名字23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
國家Switzerland
城市Basel
期間19-10-2719-10-31

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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