A model-based approach to designing developmental toxicology experiments using sea urchin embryos

Michael D. Collins, Elvis Han Cui, Seung Won Hyun, Weng Kee Wong

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

The key aim of this paper is to suggest a more quantitative approach to designing a dose–response experiment, and more specifically, a concentration–response experiment. The work proposes a departure from the traditional experimental design to determine a dose–response relationship in a developmental toxicology study. It is proposed that a model-based approach to determine a dose–response relationship can provide the most accurate statistical inference for the underlying parameters of interest, which may be estimating one or more model parameters or pre-specified functions of the model parameters, such as lethal dose, at maximal efficiency. When the design criterion or criteria can be determined at the onset, there are demonstrated efficiency gains using a more carefully selected model-based optimal design as opposed to an ad-hoc empirical design. As an illustration, a model-based approach was theoretically used to construct efficient designs for inference in a developmental toxicity study of sea urchin embryos exposed to trimethoprim. This study compares and contrasts the results obtained using model-based optimal designs versus an ad-hoc empirical design.

原文English
頁(從 - 到)919-932
頁數14
期刊Archives of Toxicology
96
發行號3
DOIs
出版狀態Published - 2022 3月

All Science Journal Classification (ASJC) codes

  • 毒理學
  • 健康、毒理學和誘變

指紋

深入研究「A model-based approach to designing developmental toxicology experiments using sea urchin embryos」主題。共同形成了獨特的指紋。

引用此