A Multi-Inlet Microfluidic Nozzle Head with Shape Memory Alloy-Based Switching for Biomaterial Printing with Precise Flow Control

Karthick Mani, Wei Chen Lin, Chun Fang Wang, Bivas Panigrahi, Yong Jin Wu, Cheng Lung Wu, Chia Yuan Chen

研究成果: Article同行評審

摘要

3D bioprinting is one of the rapidly evolving fields of tissue engineering where microengineering meets cells biology within an unprecedented precision to construct tissue structures of various forms with complexity. However, enabling simultaneous printing of heterogeneous biomaterial along with scaffold components through the currently available printers is still considered as a major challenge due to the lack of instrumentation. Flow control is one of the major issues associated with the process. In this aspect, a microfluidic nozzle head equipped with two shape-memory alloy (SMA) actuators was proposed and integrated with a commercially available 3D printer to assist the biomaterial printing in a more systematic manner. The SMA actuator restrains the amount of flows for fabricating the desired scaffold components. Experimental results illustrated that the use of SMA actuator ensued a rapid and precise flow control of biomaterial and can further facilitate to maintain the width of any printed structures. As a proof of concept for the profound biomedical applications with the present manufacturing configuration, a 3D printed hydrogel platform was fabricated with demonstrated characters for later cell seeding after the printing further opens a new chapter in terms of biomaterial printing.

原文English
頁(從 - 到)340-348
頁數9
期刊Biochip Journal
14
發行號4
DOIs
出版狀態Published - 2020 十二月

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

指紋 深入研究「A Multi-Inlet Microfluidic Nozzle Head with Shape Memory Alloy-Based Switching for Biomaterial Printing with Precise Flow Control」主題。共同形成了獨特的指紋。

引用此