A non-invasive acoustic-trapping of zebrafish microfluidics

Karthick Mani, Chia Yuan Chen

研究成果: Article同行評審

摘要

Zebrafish is an emerging alternative model in behavioral and neurological studies for pharmaceutical applications. However, little is known regarding the effects of noise exposure on laboratory-grown zebrafish. Accordingly, this study commenced by exposing zebrafish embryos to loud background noise (≥200 Hz, 80 ± 10 dB) for five days in a microfluidic environment. The noise exposure was found to affect the larvae hatching rate, larvae length, and swimming performance. A microfluidic platform was then developed for the sorting/trapping of hatched zebrafish larvae using a non-invasive method based on light cues and acoustic actuation. The experimental results showed that the proposed method enabled zebrafish larvae to be transported and sorted into specific chambers of the microchannel network in the desired time frame. The proposed non-invasive trapping method thus has potentially profound applications in drug screening.

原文English
文章編號014109
期刊Biomicrofluidics
15
發行號1
DOIs
出版狀態Published - 2021 一月 1

All Science Journal Classification (ASJC) codes

  • 生物醫學工程
  • 材料科學(全部)
  • 凝聚態物理學
  • 流體流動和轉移過程
  • 膠體和表面化學

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