A novel density-based neural mass model for simulating neuronal network dynamics with conductance-based synapses and membrane current adaptation

Chih Hsu Huang, Chou Ching K. Lin

研究成果: Article同行評審

摘要

Despite its success in understanding brain rhythms, the neural mass model, as a low-dimensional mean-field network model, is phenomenological in nature, so that it cannot replicate some of rich repertoire of responses seen in real neuronal tissues. Here, using a colored-synapse population density method, we derived a novel neural mass model, termed density-based neural mass model (dNMM), as the mean-field description of network dynamics of adaptive exponential integrate-and-fire (aEIF) neurons, in which two critical neuronal features, i.e., voltage-dependent conductance-based synaptic interactions and adaptation of firing rate responses, were included. Our results showed that the dNMM was capable of correctly estimating firing rate responses of a neuronal population of aEIF neurons receiving stationary or time-varying excitatory and inhibitory inputs. Finally, it was also able to quantitatively describe the effect of spike-frequency adaptation in the generation of asynchronous irregular activity of excitatory–inhibitory cortical networks. We conclude that in terms of its biological reality and calculation efficiency, the dNMM is a suitable candidate to build significantly large-scale network models involving multiple brain areas, where the neuronal population is the smallest dynamic unit.

原文English
頁(從 - 到)183-197
頁數15
期刊Neural Networks
143
DOIs
出版狀態Published - 2021 十一月

All Science Journal Classification (ASJC) codes

  • 認知神經科學
  • 人工智慧

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