A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer

Po Shun Wang, Cheng Han Chou, Cheng Han Lin, Yun Chin Yao, Hui Chuan Cheng, Hao Yi Li, Yu Chung Chuang, Chia Ning Yang, Luo Ping Ger, Yu Chia Chen, Forn Chia Lin, Tang Long Shen, Michael Hsiao, Pei Jung Lu

研究成果: Article

21 引文 斯高帕斯(Scopus)

摘要

Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo. Furthermore, we found linc-ZNF469-3 physically interacted with miR-574-5p and overexpression of miR-574-5p attenuated ZEB1 expression. Importantly, endogenous high expressions of linc-ZNF469-3 and ZEB1 were correlated with tumor recurrence in TNBC patients with lung metastasis. Taken together, our findings suggested that linc-ZNF469-3 promotes lung metastasis of TNBC through miR-574-5p-ZEB1 signaling axis and may be used as potential prognostic marker for TNBC patients.

原文English
頁(從 - 到)4662-4678
頁數17
期刊Oncogene
37
發行號34
DOIs
出版狀態Published - 2018 八月 23

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Wang, P. S., Chou, C. H., Lin, C. H., Yao, Y. C., Cheng, H. C., Li, H. Y., Chuang, Y. C., Yang, C. N., Ger, L. P., Chen, Y. C., Lin, F. C., Shen, T. L., Hsiao, M., & Lu, P. J. (2018). A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer. Oncogene, 37(34), 4662-4678. https://doi.org/10.1038/s41388-018-0293-1