A novel microchip system integrated with gold nano-electrode ensemble for electrochemical determination of hyaluronic acid

Chun Mao Chen, Ming-Long Yeh, Ya Ting Chuang, Che Hsin Lin, Chi Sheng Chien

研究成果: Conference contribution

摘要

This paper proposes an innovative microfluidic device for hyaluronic acid (HA) extraction and electrochemical detection utilizing PMMA based microchip that integrated with gold nanoelectrode ensemble (GNEE). Gold nanoelectrode ensemble is fabricated using electroless deposition in a thin polycarbonate (PC) film and then directly bonded onto the PMMA substrate for high performance electrochemical detection. In the study, microwave is firstly used to decrease the interference of protein on the working electrode, and then electrostatic force is used to separate and extract HA in the rat serum sample. The used of GNEE electrodes in the microchip not only enhances the signal but also decreases the background noises, resulting a high detection limit of 0.1 mg/mL for HA, and showing good linear responses in the concentration range of 10 mg/mL-0.1 mg/mL (R2=0.956). The proposed microchip device provides a fast detection method for hyaluronic acid analysis.

原文English
主出版物標題IEEE Sensors 2009 Conference - SENSORS 2009
頁面1788-1791
頁數4
DOIs
出版狀態Published - 2009 十二月 1
事件IEEE Sensors 2009 Conference - SENSORS 2009 - Christchurch, New Zealand
持續時間: 2009 十月 252009 十月 28

出版系列

名字Proceedings of IEEE Sensors

Other

OtherIEEE Sensors 2009 Conference - SENSORS 2009
國家New Zealand
城市Christchurch
期間09-10-2509-10-28

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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