A novel oxidative free radical reaction between 2-amino-1,4-benzoquinones and benzoylacetonitriles

Che Ping Chuang, An I. Tsai

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

The manganese(III) initiated oxidative free radical reaction between 2-amino-1,4-benzoquinones and benzoylacetonitriles is described. This free radical reaction provides a novel method for the synthesis of spirodione 3 and spirolactone 4. With 5,6-dimethyl-2-methylamino-1,4-benzoquinone, spirodione 3 was obtained exclusively. On the contrary, with 5-methyl-2-methylamino-1,4-benzoquinone, spirolactone 4 was produced in high chemo- and regioselectivity. By heating with sodium acetate, spirodione 3 can be converted to 4 effectively.

原文English
頁(從 - 到)9712-9717
頁數6
期刊Tetrahedron
63
發行號39
DOIs
出版狀態Published - 2007 9月 24

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 藥物發現
  • 有機化學

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