A novel zwitterionic polymer for surface modification of polypropylene: Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility

Chia Sheng Hung, Chi Hui Cheng, Jui-Che Lin

研究成果: Conference contribution

摘要

Statement of Purpose: Antifouling is one of the most important characteristics required for materials intended for biomedical applications. In can lead to the reducing protein adsorption and subsequent bacterial adhesion or platelet adhesion. It is hypothesized that the nonfouling ability is tightly correlated with a hydration layer near the surface which forms a physical and energetic barrier to prevent protein adsorption on the surface. So far, there are three hydrophilic materials, 2-hydroxyethyl methacrylate (HEMA), oligo (ethylene glycol) (OEG) or poly (ethylene glycol) (PEG) and zwitterionic polymers have been suggested to be resistant to protein adsorption in different testing settings. But the failure in protein adsorption testing in physiological relevant conditions (e.g. undiluted human blood serum or plasma) for the polyHEMA and likely decomposition of PEG and OEG groups by the oxygen and transition metal ions found in most biochemically relevant solutions have rendered the zwitterionic materials to be the choice for preparing the nonfouling surface layer.

原文English
主出版物標題Society for Biomaterials Annual Meeting and Exposition 2019
主出版物子標題The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
發行者Society for Biomaterials
頁數1
ISBN(電子)9781510883901
出版狀態Published - 2019 一月 1
事件42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
持續時間: 2019 四月 32019 四月 6

出版系列

名字Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
40
ISSN(列印)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
國家United States
城市Seattle
期間19-04-0319-04-06

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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