A piezoelectric quartz crystal sensor for the determination of coagulation time in plasma and whole blood

Tzong Jih Cheng, Hsien Chang Chang, Tsun Mei Lin

研究成果: Article同行評審

43 引文 斯高帕斯(Scopus)

摘要

A Piezoelectric Quartz Crystal (PQC) system possessing an adequate sensitivity to a slight viscosity change is employed to monitor the blood coagulation. In the case of an anticoagulated plasma specimen, prothrombin time (PT) was determined by the PQC sensor on the basis of the introduction of tissue thromboplastin (TF) and calcium ion. Discussing the PQC data statistically, we found that at 90% of the total frequency shift (Δf) the best linear relationship in a double-logarithmic plot of PT versus TF concentration in the range of 5.466 ~ 22.311 unit/ml is shown. The PQC result was compared with commercial optical coagulometry and showed a good linear correlation (ca. 0.98). The clotting and recalcification of whole blood were also studied by the PQC system. The testing time for one measurement could be completed within 20 min. and had a good agreement with that obtained conventionally.

原文English
頁(從 - 到)147-156
頁數10
期刊Biosensors and Bioelectronics
13
發行號2
DOIs
出版狀態Published - 1998 二月 1

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 生物物理學
  • 生物醫學工程
  • 電化學

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