A pilot study of neoadjuvant paclitaxel and radiation with correlative molecular studies in stage II/III breast cancer.

A. Chakravarthy, B. Nicholson, M. Kelley, D. Beauchamp, D. Johnson, M. Frexes-Steed, J. Simpson, Yu Shyr, J. Pietenpol

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11 引文 斯高帕斯(Scopus)

摘要

A commonly used approach to the management of locally advanced breast cancer currently involves neoadjuvant chemotherapy, followed by surgery and radiation. Earlier neoadjuvant regimens had utilized doxorubicin, making concurrent treatment with radiation less desirable given dose-limiting normal tissue toxicities. With the development of paclitaxel, we can now reconsider the use of concurrent chemoradiation in the treatment of breast cancer. Although paclitaxel is a known radiation sensitizer, its precise mechanism of action is still unclear. One of its proposed mechanisms is that it binds tubulin and induces an M-phase arrest. As cells in M-phase are very sensitive to radiation, it thereby increases radiation sensitivity. The ability to predict tumor response for individual patients would allow us to tailor subsequent therapy for the individual patient. This study is designed to evaluate if paclitaxel's effects on the cell cycle of an individual patient can predict the responsiveness of that patient's tumor to paclitaxel and radiation. Patients will be treated with 3 cycles of paclitaxel followed by concurrent paclitaxel and radiation prior to definitive surgery.

原文English
頁(從 - 到)68-71
頁數4
期刊Clinical breast cancer
1
發行號1
DOIs
出版狀態Published - 2000 一月 1

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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