Acquisition of a variety of physiological signals is essential for monitoring and investigation of some specific diseases. Many medical instruments have been well developed and deployed in medical institutes, but many of them are bulky and clumsy for daily recording of subjects' activity. A distributed multi-channel physiological data monitoring system was developed for integrating versatile sensor modules attached in different parts of body. The physiological signals are acquired and processed, and the raw or preprocessed data are then transmitted through wireless communications to a backend server and storage for long-term recording and study. Time synchronization is critical for data fusion and therefore more accurate state discrimination can be achieved. Ubiquitous data access is fundamental, so a smart mobile device in a virtual computing environment will help on this requirement.