A portable wireless online closed-loop seizure controller in freely moving rats

Chung Ping Young, Sheng Fu Liang, Da Wei Chang, Yi Cheng Liao, Fu Zen Shaw, Chao Hsien Hsieh

研究成果: Article

44 引文 斯高帕斯(Scopus)

摘要

A considerable portion of epilepsy cannot be well treated by available therapies nowadays. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. A portable wireless online closed-loop seizure controller in freely moving rats was developed and shown with several aspects of advantages, including the following: 1) high accuracy of real-time seizure detection (9299% during wakesleep states); 2) low cost; and 3) low power consumption. The seizure detection latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. The observation showed that the stimulation elicited no abnormal behavior and had no sleep interruption to the subjects. The experiment data supported the functional possibility of a real-time closed-loop seizure controller.

原文English
文章編號5499016
頁(從 - 到)513-521
頁數9
期刊IEEE Transactions on Instrumentation and Measurement
60
發行號2
DOIs
出版狀態Published - 2011 二月 1

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Electrical and Electronic Engineering

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