A randomized controlled study of low‐dose and high‐dose terlipressin in the control of acute oesophageal variceal haemorrhage

TING‐TSUNG ‐T CHANG, FA‐YAUH ‐Y LEE, YANG‐TE ‐T TSAI, KWOK‐HUNG ‐H LAI, YEE CHAO, HSIAO‐CHUNG ‐C HSIA, HAN‐CHIEH ‐C LIN, SUN‐SANG ‐S WANG, SHOU‐DONG ‐D LEE, KWANG‐JUEI ‐J LO

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9 引文 斯高帕斯(Scopus)

摘要

A randomized controlled trial was designed to investigate whether a high dose of terlipressin could control acute variceal haemorrhage more effectively than a low dose of terlipressin. Forty cirrhotic patients with bleeding oesophageal varices were included, with low‐dose terlipressin in 21 patients and high‐dose terlipressin in 19 patients. The two groups of patients were similarly matched for all parameters on admission. High‐dose terlipressin (84%) seemed to be more effective in the initial control of bleeding than low‐dose terlipressin (67%); however this difference was not significant. Complete control of bleeding during 24 h of drug infusion was achieved in 53% of patients receiving high‐dose terlipressin and in 48% of those treated with low‐dose terlipressin (P > 0.05). There were no major complications in either group. Mortality in relation to variceal bleeding and transfusion requirements were similar in the two groups. This study shows that high dose terlipressin is not superior to low dose terlipressin in acute variceal bleeding.

原文English
頁(從 - 到)481-484
頁數4
期刊Journal of Gastroenterology and Hepatology
6
發行號5
DOIs
出版狀態Published - 1991 10月

All Science Journal Classification (ASJC) codes

  • 肝病
  • 消化內科

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