摘要
Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHFDSS. Lack of a suitable animal model for DHFDSS has hindered progress in defining the etiology of DHFDSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.
| 原文 | English |
|---|---|
| 頁（從 - 到） | E24-E35 |
| 期刊 | Annals of the New York Academy of Sciences |
| 卷 | 1171 |
| 發行號 | SUPPL. 1 |
| DOIs | |
| 出版狀態 | Published - 2009 九月 |
指紋
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
引用此文
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A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. / Noisakran, Sansanee; Chokephaibulkit, Kulkanya; Songprakhon, Pucharee; Onlamoon, Nattawat; Hsiao, Hui Mien; Villinger, Francois; Ansari, Aftab; Perng, Guey Chuen.
於: Annals of the New York Academy of Sciences, 卷 1171, 編號 SUPPL. 1, 09.2009, p. E24-E35.研究成果: Review article
TY - JOUR
T1 - A re-evaluation of the mechanisms leading to dengue hemorrhagic fever
AU - Noisakran, Sansanee
AU - Chokephaibulkit, Kulkanya
AU - Songprakhon, Pucharee
AU - Onlamoon, Nattawat
AU - Hsiao, Hui Mien
AU - Villinger, Francois
AU - Ansari, Aftab
AU - Perng, Guey Chuen
PY - 2009/9
Y1 - 2009/9
N2 - Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHFDSS. Lack of a suitable animal model for DHFDSS has hindered progress in defining the etiology of DHFDSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.
AB - Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHFDSS. Lack of a suitable animal model for DHFDSS has hindered progress in defining the etiology of DHFDSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.
UR - http://www.scopus.com/inward/record.url?scp=70350450851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350450851&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05050.x
DO - 10.1111/j.1749-6632.2009.05050.x
M3 - Review article
C2 - 19751399
AN - SCOPUS:70350450851
VL - 1171
SP - E24-E35
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - SUPPL. 1
ER -