A re-evaluation of the mechanisms leading to dengue hemorrhagic fever

Sansanee Noisakran, Kulkanya Chokephaibulkit, Pucharee Songprakhon, Nattawat Onlamoon, Hui Mien Hsiao, Francois Villinger, Aftab Ansari, Guey Chuen Perng

研究成果: Review article同行評審

42 引文 斯高帕斯(Scopus)


Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHFDSS. Lack of a suitable animal model for DHFDSS has hindered progress in defining the etiology of DHFDSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.

頁(從 - 到)E24-E35
期刊Annals of the New York Academy of Sciences
發行號SUPPL. 1
出版狀態Published - 2009 9月

All Science Journal Classification (ASJC) codes

  • 神經科學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 科學史與哲學


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