A simple electrokinetic protein preconcentrator utilizing nano-interstices

Yu-Hung Chen, Hsuan Franziska Wu, Tamara G. Amstislavskaya, Chang Yu Li, Chun Ping Jen

研究成果: Article

9 引文 斯高帕斯(Scopus)

摘要

This work proposes a simple method for creating nanofluidic channels for protein preconcentration through self-assembled gold nanoparticles (AuNPs) using the exclusion-enrichment effect. A depletion force is elicited in nano-interstices among self-assembled AuNPs due to the overlap of electrical double layers (EDLs); therefore, proteins quickly accumulate. The experimental results show that the generation of depletion forces is correlated with the size of the AuNPs. The self-assembled monolayer of AuNPs (13 nm in diameter) can successfully preconcentrate proteins through effective EDL overlapping. This approach provides a new process to produce nanochannels that does not require high-voltage or time-consuming fabrication.

原文English
文章編號024121
期刊Biomicrofluidics
10
發行號2
DOIs
出版狀態Published - 2016 三月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Materials Science(all)
  • Genetics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

引用此

Chen, Y-H., Wu, H. F., Amstislavskaya, T. G., Li, C. Y., & Jen, C. P. (2016). A simple electrokinetic protein preconcentrator utilizing nano-interstices. Biomicrofluidics, 10(2), [024121]. https://doi.org/10.1063/1.4946768