A thiocyanate based molecular salt as an effective intercalator towards CT DNA

Bhaskar Biswas, Hui Lien Tsai, Niranjan Kole

研究成果: Article同行評審

摘要

A previously reported thiocyanate based hybrid molecular salt l(dpaH)+(NCS)-] (1) (dpa = 2,2'-dipyridylamine) has been synthesized and structurally characterized. In this work, we have investigated the binding property of this salt with Calf Thymas DNA (CT DNA) using absorption and emission titration, thermal melting studies, viscosity experiments and circular dichroism studies. Binding curves constructed from absorption and emission changes indicate that, the molecular salt displays higher binding affinity (>105 M-1) towards DNA. Spectroscopic and hydrodynamic investigations reveal that molecular salt 1 behaves as an effective DNA intercalator.

原文English
頁(從 - 到)2101-2105
頁數5
期刊Journal of the Indian Chemical Society
91
發行號11
出版狀態Published - 2014 十一月

All Science Journal Classification (ASJC) codes

  • 藥物發現
  • 物理與理論化學
  • 有機化學
  • 無機化學
  • 電化學

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