A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia

Ya Ning Chang, Matthew A. Lambon Ralph

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

Understanding the processes underlying normal, impaired, and recovered language performance has been a long-standing goal for cognitive and clinical neuroscience. Many verbally described hypotheses about language lateralization and recovery have been generated. However, they have not been considered within a single, unified, and implemented computational framework, and the literatures on healthy participants and patients are largely separated. These investigations also span different types of data, including behavioral results and functional MRI brain activations, which augment the challenge for any unified theory. Consequently, many key issues, apparent contradictions, and puzzles remain to be solved. We developed a neurocomputational, bilateral pathway model of spoken language production, designed to provide a unified framework to simulate different types of data fromhealthy participants and aphasic patients. The model encapsulates key computational principles (differential computational capacity, emergent division of labor across pathways, experience-dependent plasticityrelated recovery) and provides an explanation for the bilateral yet asymmetric lateralization of language in healthy participants, chronic aphasia after left rather than right hemisphere lesions, and the basis of partial recovery in patients. The model provides a formal basis for understanding the relationship between behavioral performance and brain activation. The unified model is consistent with the degeneracy and variable neurodisplacement theories of language recovery, and adds computational insights to these hypotheses regarding the neural machinery underlying language processing and plasticityrelated recovery following damage.

原文English
頁(從 - 到)32779-32790
頁數12
期刊Proceedings of the National Academy of Sciences of the United States of America
117
發行號51
DOIs
出版狀態Published - 2020 12月 22

All Science Journal Classification (ASJC) codes

  • 多學科

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