A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

Li Xing Yang, Yu Cheng Liu, Chang Hui Cho, Yi Rou Chen, Chan Shan Yang, Yin Lin Lu, Zhiming Zhang, Yi Tseng Tsai, Yu Cheng Chin, Jiashing Yu, Hsiu Min Pan, Wei Rou Jiang, Zi Chun Chia, Wei Shiang Huang, Yu Lin Chiu, Chun Kai Sun, Yu Ting Huang, Li Ming Chen, Ken Tsung Wong, Han Min HuangChih Hsin Chen, Yuan Jay Chang, Chih Chia Huang, Tzu Ming Liu

研究成果: Article同行評審

摘要

The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

原文English
文章編號311
期刊Journal of Nanobiotechnology
20
發行號1
DOIs
出版狀態Published - 2022 12月

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 醫藥(雜項)
  • 分子醫學
  • 生物醫學工程
  • 應用微生物與生物技術
  • 藥學科學

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