Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Jen Hui Tsou, Kung-Chao Chang, Pey Yi Chang-Liao, Shu Ting Yang, Chung-Ta Lee, Ya-Ping Chen, Yi Chao Lee, Po-Wen Lin, Jenq-Chang Lee, Meng-Ru Shen, Chin Kai Chuang, Wen Chang Chang, Ju-Ming Wang, Liang-Yi Hung

研究成果: Article

21 引文 (Scopus)

摘要

Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human cancer specimens shows that the expression of AURKC is increased in cervical cancer, and is highly correlated with staging in colorectal cancer. Over-expressed AURKC-GFP localizes to the centromeric regions of mitotic chromosomes and results in a decreased level of AURKB, a key regulator of spindle checkpoint. Expression of AURKC is down-regulated by PLZF, a transcriptional repressor, through recruitment to its promoter region. The expression levels of PLZF and AURKC mRNA display opposite patterns in human cervical and colorectal cancers. Taken together, our results provide important insights into human cancers with AURKC expression, which may serve as a potential target for cancer therapy in the future.

原文English
頁(從 - 到)243-254
頁數12
期刊Journal of Pathology
225
發行號2
DOIs
出版狀態Published - 2011 十月 1

指紋

Epithelial Cells
Neoplasms
Colorectal Neoplasms
Thyroid Neoplasms
Uterine Cervical Neoplasms
Genetic Promoter Regions
Cell Movement
Phosphotransferases
Chromosomes
Cell Line
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

引用此文

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abstract = "Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human cancer specimens shows that the expression of AURKC is increased in cervical cancer, and is highly correlated with staging in colorectal cancer. Over-expressed AURKC-GFP localizes to the centromeric regions of mitotic chromosomes and results in a decreased level of AURKB, a key regulator of spindle checkpoint. Expression of AURKC is down-regulated by PLZF, a transcriptional repressor, through recruitment to its promoter region. The expression levels of PLZF and AURKC mRNA display opposite patterns in human cervical and colorectal cancers. Taken together, our results provide important insights into human cancers with AURKC expression, which may serve as a potential target for cancer therapy in the future.",
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Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. / Tsou, Jen Hui; Chang, Kung-Chao; Chang-Liao, Pey Yi; Yang, Shu Ting; Lee, Chung-Ta; Chen, Ya-Ping; Lee, Yi Chao; Lin, Po-Wen; Lee, Jenq-Chang; Shen, Meng-Ru; Chuang, Chin Kai; Chang, Wen Chang; Wang, Ju-Ming; Hung, Liang-Yi.

於: Journal of Pathology, 卷 225, 編號 2, 01.10.2011, p. 243-254.

研究成果: Article

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AU - Chang, Kung-Chao

AU - Chang-Liao, Pey Yi

AU - Yang, Shu Ting

AU - Lee, Chung-Ta

AU - Chen, Ya-Ping

AU - Lee, Yi Chao

AU - Lin, Po-Wen

AU - Lee, Jenq-Chang

AU - Shen, Meng-Ru

AU - Chuang, Chin Kai

AU - Chang, Wen Chang

AU - Wang, Ju-Ming

AU - Hung, Liang-Yi

PY - 2011/10/1

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N2 - Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human cancer specimens shows that the expression of AURKC is increased in cervical cancer, and is highly correlated with staging in colorectal cancer. Over-expressed AURKC-GFP localizes to the centromeric regions of mitotic chromosomes and results in a decreased level of AURKB, a key regulator of spindle checkpoint. Expression of AURKC is down-regulated by PLZF, a transcriptional repressor, through recruitment to its promoter region. The expression levels of PLZF and AURKC mRNA display opposite patterns in human cervical and colorectal cancers. Taken together, our results provide important insights into human cancers with AURKC expression, which may serve as a potential target for cancer therapy in the future.

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