TY - JOUR
T1 - Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a western diet
AU - Cheng, Xiwen
AU - Guo, Shuang
AU - Liu, Yu
AU - Chu, Hao
AU - Hakimi, Parvin
AU - Berger, Nathan A.
AU - Hanson, Richard W.
AU - Kao, Hung Ying
PY - 2013/10/11
Y1 - 2013/10/11
N2 - The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.
AB - The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.
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U2 - 10.1074/jbc.M113.487595
DO - 10.1074/jbc.M113.487595
M3 - Article
C2 - 23986437
AN - SCOPUS:84885583292
SN - 0021-9258
VL - 288
SP - 29746
EP - 29759
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 41
ER -