Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a western diet

Xiwen Cheng, Shuang Guo, Yu Liu, Hao Chu, Parvin Hakimi, Nathan A. Berger, Richard W. Hanson, Hung Ying Kao

研究成果: Article

15 引文 斯高帕斯(Scopus)

摘要

The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.

原文English
頁(從 - 到)29746-29759
頁數14
期刊Journal of Biological Chemistry
288
發行號41
DOIs
出版狀態Published - 2013 十月 11

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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